Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3412368..3412614 Replicon chromosome
Accession NZ_CP007025
Organism Escherichia albertii KF1

Toxin (Protein)


Gene name hokX Uniprot ID S1PD89
Locus tag EAKF1_RS16945 Protein ID WP_000956458.1
Coordinates 3412462..3412614 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokX
Locus tag -
Coordinates 3412368..3412420 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAKF1_RS16930 3407772..3409571 + 1800 WP_025238480.1 NADPH-dependent assimilatory sulfite reductase flavoprotein subunit -
EAKF1_RS16935 3409571..3411283 + 1713 WP_025238481.1 assimilatory sulfite reductase (NADPH) hemoprotein subunit -
EAKF1_RS16940 3411463..3412197 + 735 WP_025238482.1 phosphoadenosine phosphosulfate reductase -
- 3412368..3412420 - 53 - - Antitoxin
EAKF1_RS16945 3412462..3412614 + 153 WP_000956458.1 type I toxin-antitoxin system Hok family toxin Toxin
EAKF1_RS16950 3412740..3413777 - 1038 WP_025238483.1 alkaline phosphatase isozyme conversion aminopeptidase -
EAKF1_RS16955 3414030..3414938 + 909 WP_000372392.1 sulfate adenylyltransferase subunit CysD -
EAKF1_RS16960 3414940..3416367 + 1428 WP_025238484.1 sulfate adenylyltransferase subunit CysN -
EAKF1_RS16965 3416367..3416972 + 606 WP_024164730.1 adenylyl-sulfate kinase -
EAKF1_RS16970 3417022..3417345 + 324 WP_001246114.1 DUF3561 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5558.77 Da        Isoelectric Point: 7.6757

>T45867 WP_000956458.1 NZ_CP007025:3412462-3412614 [Escherichia albertii KF1]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Download         Length: 153 bp

>T45867 NZ_CP007025:3412462-3412614 [Escherichia albertii KF1]
ATGCTGACAAAATATGCCCTTGTGGCAATCATAGTGCTGTGTTGTACAGTGCTGGGATTCACGCTGATGGTAGGCGACTC
GTTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 53 bp

>AT45867 NZ_CP007025:c3412420-3412368 [Escherichia albertii KF1]
TTAGGTTCGAACGTAGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TJ83

Antitoxin

Download structure file

References