Detailed information of TA system TA045860

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-ohsC/SymE(toxin)
• Location: 1592693..1593105
• Replicon: chromosome
• Accession: NZ_CP007025
• Organism: Escherichia albertii KF1

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A7U8ZC55
• Locus tag: EAKF1_RS07980
• Protein ID: WP_025237738.1
• Coordinates: 1592764..1593105 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	ohsC
Locus tag	-
Coordinates	1592693..1592769 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EAKF1_RS07970	1589588..1591177	+	1590	WP_025237737.1	type I restriction-modification system methyltransferase	-
EAKF1_RS26255	1591612..1592536	+	925	Protein_1524	restriction endonuclease subunit S	-
-	1592693..1592769	-	77	NuclAT_6	-	Antitoxin
-	1592693..1592769	-	77	NuclAT_6	-	Antitoxin
-	1592693..1592769	-	77	NuclAT_6	-	Antitoxin
-	1592693..1592769	-	77	NuclAT_6	-	Antitoxin
-	1592693..1592769	-	77	NuclAT_7	-	Antitoxin
-	1592693..1592769	-	77	NuclAT_7	-	Antitoxin
-	1592693..1592769	-	77	NuclAT_7	-	Antitoxin
-	1592693..1592769	-	77	NuclAT_7	-	Antitoxin
EAKF1_RS07980	1592764..1593105	+	342	WP_025237738.1	endoribonuclease SymE	Toxin
EAKF1_RS26900	1593152..1595248	-	2097	WP_025237739.1	DUF262 domain-containing protein	-
EAKF1_RS26905	1595473..1595646	+	174	Protein_1527	GntR family transcriptional regulator	-
EAKF1_RS07995	1595798..1596729	-	932	Protein_1528	Rpn family recombination-promoting nuclease/putative transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1592180..1603023	10843

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12310.12 Da
• Isoelectric Point: 7.8219

>T45860 WP_025237738.1 NZ_CP007025:1592764-1593105 [Escherichia albertii KF1]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAIDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T45860 NZ_CP007025:1592764-1593105 [Escherichia albertii KF1]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGCCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGATAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCCCCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGAATTTATTGGGGTGATTGC
CGGTAAACAGAAAGTCGCCTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT45860 NZ_CP007025:c1592769-1592693 [Escherichia albertii KF1]
AGTCATGATTACTATTCTCCATAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A7U8ZC55

Antitoxin