Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1445170..1445807 Replicon chromosome
Accession NZ_CP006957
Organism Mannheimia haemolytica USDA-ARS-USMARC-184

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag B824_RS07310 Protein ID WP_040080900.1
Coordinates 1445170..1445475 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag B824_RS07315 Protein ID WP_040080901.1
Coordinates 1445487..1445807 (+) Length 107 a.a.

Genomic Context

B824_RS07310B824_RS07315B824_RS07320B824_RS07270B824_RS12800B824_RS07285B824_RS07290B824_RS07295B824_RS07300B824_RS07305B824_RS07325B824_RS07335B824_RS07340B824_RS07345B824_RS07350B824_RS07355B824_RS07360B824_RS07365
Location: 1445170..1445475 (306 bp)
Type: Toxin
Protein ID: WP_040080900.1
Location: 1445487..1445807 (321 bp)
Type: Antitoxin
Protein ID: WP_040080901.1
Location: 1445874..1446332 (459 bp)
Type: Others
Protein ID: WP_040080902.1
Location: 1441425..1441922 (498 bp)
Type: Others
Protein ID: WP_040080897.1
Location: 1442312..1442545 (234 bp)
Type: Others
Protein ID: WP_162839428.1
Location: 1442511..1442840 (330 bp)
Type: Others
Protein ID: WP_040080898.1
Location: 1442841..1443437 (597 bp)
Type: Others
Protein ID: WP_020824120.1
Location: 1443452..1443811 (360 bp)
Type: Others
Protein ID: WP_165876904.1
Location: 1443947..1444420 (474 bp)
Type: Others
Protein ID: WP_006251969.1
Location: 1444410..1444979 (570 bp)
Type: Others
Protein ID: WP_040080899.1
Location: 1446386..1447426 (1041 bp)
Type: Others
Protein ID: WP_040080511.1
Location: 1447561..1448022 (462 bp)
Type: Others
Protein ID: WP_020824123.1
Location: 1448043..1448645 (603 bp)
Type: Others
Protein ID: WP_040080903.1
Location: 1448642..1449289 (648 bp)
Type: Others
Protein ID: WP_032844508.1
Location: 1449289..1449573 (285 bp)
Type: Others
Protein ID: WP_032844512.1
Location: 1449711..1450062 (352 bp)
Type: Others
Protein ID: Protein_1372
Location: 1450059..1450244 (186 bp)
Type: Others
Protein ID: WP_052437193.1
Location: 1450356..1450799 (444 bp)
Type: Others
Protein ID: WP_006252074.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
B824_RS072701441425..1441922-498WP_040080897.1hypothetical protein-
B824_RS128001442312..1442545-234WP_162839428.1hypothetical protein-
B824_RS072851442511..1442840-330WP_040080898.1DUF2570 family protein-
B824_RS072901442841..1443437-597WP_020824120.1glycoside hydrolase family 19 protein-
B824_RS072951443452..1443811-360WP_165876904.1phage holin, lambda family-
B824_RS073001443947..1444420-474WP_006251969.1hypothetical protein-
B824_RS073051444410..1444979-570WP_040080899.1recombination protein NinG-
B824_RS073101445170..1445475+306WP_040080900.1type II toxin-antitoxin system RelE/ParE family toxinToxin
B824_RS073151445487..1445807+321WP_040080901.1HigA family addiction module antidote proteinAntitoxin
B824_RS073201445874..1446332+459WP_040080902.1hypothetical protein-
B824_RS073251446386..1447426-1041WP_040080511.1IS481 family transposase-
B824_RS073351447561..1448022-462WP_020824123.1DUF1367 family protein-
B824_RS073401448043..1448645-603WP_040080903.1adenine methyltransferase-
B824_RS073451448642..1449289-648WP_032844508.1bacteriophage replication protein-
B824_RS073501449289..1449573-285WP_032844512.1hypothetical protein-
B824_RS073551449711..1450062-352Protein_1372hypothetical protein-
B824_RS073601450059..1450244-186WP_052437193.1helix-turn-helix domain-containing protein-
B824_RS073651450356..1450799-444WP_006252074.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--1422815..146431941504
-flankIS/Tn--1446386..14474261040


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(8-97)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-82)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11995.61 Da        Isoelectric Point: 6.4692

>T45826 WP_040080900.1 NZ_CP006957:1445170-1445475 [Mannheimia haemolytica USDA-ARS-USMARC-184]
MFNLTEAHFRDEALYRFFQYGEVSRTIPANLTSVLARKLDMINAAEKLNDLRSPPANRLELLEPKQNNVYSIRVNKQYRL
IFKFENNELSDLYLDPHNYDL

Download         Length: 306 bp

>T45826 NZ_CP006957:1445170-1445475 [Mannheimia haemolytica USDA-ARS-USMARC-184]
ATGTTTAACTTAACCGAAGCCCATTTTAGAGATGAAGCTCTTTATCGGTTCTTCCAATATGGCGAAGTCAGCAGAACAAT
CCCTGCTAATCTCACAAGCGTATTAGCTCGCAAACTGGATATGATTAATGCAGCTGAAAAGCTGAATGACTTACGCAGTC
CGCCTGCTAATCGCTTAGAGTTACTTGAGCCGAAACAGAACAACGTCTATTCAATTCGAGTAAACAAACAGTATCGATTG
ATTTTCAAGTTTGAAAACAATGAACTCTCTGATTTATACCTTGACCCACACAATTACGACCTATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12089.80 Da        Isoelectric Point: 6.2152

>AT45826 WP_040080901.1 NZ_CP006957:1445487-1445807 [Mannheimia haemolytica USDA-ARS-USMARC-184]
MMQRKPTPVGEILQEEFLAPLNLKIGDLVEILDVHRNTASNLVNNSCRVSPEMAFKLAKAFDTSPEFWLNLQTATDLWEL
RHNNRFQQSLDSVKAVNHWQGVPAFA

Download         Length: 321 bp

>AT45826 NZ_CP006957:1445487-1445807 [Mannheimia haemolytica USDA-ARS-USMARC-184]
ATGATGCAACGCAAACCGACCCCGGTTGGGGAAATTCTCCAGGAAGAATTTTTAGCGCCACTTAATCTTAAAATCGGCGA
CCTCGTTGAAATTTTAGACGTACACCGCAACACCGCCAGCAACCTTGTGAATAACAGTTGCCGTGTTAGTCCTGAAATGG
CATTTAAATTGGCAAAAGCCTTTGATACCAGCCCTGAATTTTGGCTCAACCTACAAACCGCAACCGATTTATGGGAACTC
CGCCATAACAACCGCTTCCAACAAAGCCTTGATAGCGTAAAAGCCGTAAATCACTGGCAAGGTGTGCCTGCATTTGCTTA
A

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References