Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
Location | 3224005..3224507 | Replicon | chromosome |
Accession | NZ_CP006834 | ||
Organism | Escherichia coli APEC O2-211 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | - |
Locus tag | APECO2_RS17140 | Protein ID | WP_000767832.1 |
Coordinates | 3224005..3224259 (-) | Length | 85 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | S1Q063 |
Locus tag | APECO2_RS17145 | Protein ID | WP_001259255.1 |
Coordinates | 3224256..3224507 (-) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
APECO2_RS17120 | 3220498..3221856 | - | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
APECO2_RS17125 | 3221846..3221908 | - | 63 | WP_010723108.1 | membrane protein YoeI | - |
APECO2_RS17130 | 3222123..3223052 | - | 930 | WP_032285344.1 | LysR family transcriptional regulator | - |
APECO2_RS17135 | 3223098..3223922 | - | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
APECO2_RS17140 | 3224005..3224259 | - | 255 | WP_000767832.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
APECO2_RS17145 | 3224256..3224507 | - | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
APECO2_RS17150 | 3224789..3224839 | + | 51 | WP_001364200.1 | his operon leader peptide | - |
APECO2_RS17160 | 3224985..3225884 | + | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
APECO2_RS17165 | 3225890..3227194 | + | 1305 | WP_024198577.1 | histidinol dehydrogenase | - |
APECO2_RS17170 | 3227191..3228261 | + | 1071 | WP_032285343.1 | histidinol-phosphate transaminase | - |
APECO2_RS17175 | 3228261..3229328 | + | 1068 | WP_032285342.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10232.66 Da Isoelectric Point: 8.0280
>T45699 WP_000767832.1 NZ_CP006834:c3224259-3224005 [Escherichia coli APEC O2-211]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHYLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHYLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T45699 NZ_CP006834:c3224259-3224005 [Escherichia coli APEC O2-211]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATTATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATTATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT45699 WP_001259255.1 NZ_CP006834:c3224507-3224256 [Escherichia coli APEC O2-211]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT45699 NZ_CP006834:c3224507-3224256 [Escherichia coli APEC O2-211]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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