45643

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 1078792..1079380 Replicon chromosome
Accession NZ_CP006827
Organism Helicobacter pylori oki898

Toxin (Protein)


Gene name TfiT Uniprot ID K7Y720
Locus tag HPOKI898_RS05050 Protein ID WP_015086299.1
Coordinates 1079099..1079380 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID X2I3W4
Locus tag HPOKI898_RS05045 Protein ID WP_025276158.1
Coordinates 1078792..1079106 (+) Length 105 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPOKI898_RS05025 1074383..1075039 + 657 WP_025277015.1 ParA family protein -
HPOKI898_RS05030 1075121..1075405 + 285 WP_000394639.1 hypothetical protein -
HPOKI898_RS05035 1075437..1076621 + 1185 WP_025276157.1 hypothetical protein -
HPOKI898_RS05040 1076646..1078533 - 1888 Protein_966 relaxase/mobilization nuclease domain-containing protein -
HPOKI898_RS05045 1078792..1079106 + 315 WP_025276158.1 hypothetical protein Antitoxin
HPOKI898_RS05050 1079099..1079380 + 282 WP_015086299.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
HPOKI898_RS05055 1079651..1081378 - 1728 WP_025276159.1 type IV secretory system conjugative DNA transfer family protein -
HPOKI898_RS05060 1081379..1081936 - 558 WP_025277016.1 hypothetical protein -
HPOKI898_RS05065 1081937..1082227 - 291 WP_000159826.1 hypothetical protein -
HPOKI898_RS05070 1082224..1082679 - 456 WP_025276161.1 hypothetical protein -
HPOKI898_RS05075 1082676..1083617 - 942 WP_025276162.1 Flp pilus assembly complex ATPase component TadA -
HPOKI898_RS05080 1083617..1083915 - 299 Protein_974 hypothetical protein -
HPOKI898_RS05085 1083912..1084175 - 264 WP_025276164.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1042825..1079654 36829


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-92)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 94 a.a.        Molecular weight: 10860.83 Da        Isoelectric Point: 10.0264

>T45643 WP_015086299.1 NZ_CP006827:1079099-1079380 [Helicobacter pylori oki898]
MLKVRTKKDFLKDFNKHILSGRITESDVASVVDCLKKQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Download         Length: 282 bp

>T45643 NZ_CP006827:1079099-1079380 [Helicobacter pylori oki898]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATTTTATCTGGGCGTATTACAGAAAGCGA
TGTTGCAAGCGTTGTTGATTGCCTAAAAAAACAAAAACCACTCCAACAAAAATATTGCGACCATGCTTTGAGTGGCAATC
TTAAAGGGCTGAGAGAGTGTCATGTTAAGCCAAACTTGTTATTGATTTATGAAATCAAAAAACAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGCGAGCTATTTAAAAAGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12212.73 Da        Isoelectric Point: 5.7657

>AT45643 WP_025276158.1 NZ_CP006827:1078792-1079106 [Helicobacter pylori oki898]
MSNIITDYSQYNEKQLHNFLNSIEKQLLKAEGDKNKAIKKIQECELQERMIRQVLAQKHSQEKEPTQSLLNTIVSKDDPE
CDVSFGDFNDFLQIAKQERERRNA

Download         Length: 315 bp

>AT45643 NZ_CP006827:1078792-1079106 [Helicobacter pylori oki898]
ATGTCAAATATTATTACAGATTACTCGCAATACAATGAAAAGCAACTGCACAATTTCTTAAACTCCATTGAAAAACAATT
GCTTAAGGCAGAAGGGGATAAAAATAAGGCGATAAAAAAAATTCAAGAGTGTGAATTGCAAGAACGAATGATCAGACAAG
TTTTAGCCCAAAAACATTCTCAAGAAAAAGAACCCACACAAAGTTTGTTAAATACGATCGTCTCAAAAGATGACCCAGAA
TGCGATGTTTCGTTTGGAGACTTCAATGATTTTTTACAAATAGCAAAACAAGAAAGAGAAAGGCGTAATGCTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB K7Y720


Antitoxin

Source ID Structure
AlphaFold DB X2I3W4

References