Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | DinJ-YafQ (relBE)/YafQ(toxin) |
Location | 1078792..1079380 | Replicon | chromosome |
Accession | NZ_CP006827 | ||
Organism | Helicobacter pylori oki898 |
Toxin (Protein)
Gene name | TfiT | Uniprot ID | K7Y720 |
Locus tag | HPOKI898_RS05050 | Protein ID | WP_015086299.1 |
Coordinates | 1079099..1079380 (+) | Length | 94 a.a. |
Antitoxin (Protein)
Gene name | TfiA | Uniprot ID | X2I3W4 |
Locus tag | HPOKI898_RS05045 | Protein ID | WP_025276158.1 |
Coordinates | 1078792..1079106 (+) | Length | 105 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HPOKI898_RS05025 | 1074383..1075039 | + | 657 | WP_025277015.1 | ParA family protein | - |
HPOKI898_RS05030 | 1075121..1075405 | + | 285 | WP_000394639.1 | hypothetical protein | - |
HPOKI898_RS05035 | 1075437..1076621 | + | 1185 | WP_025276157.1 | hypothetical protein | - |
HPOKI898_RS05040 | 1076646..1078533 | - | 1888 | Protein_966 | relaxase/mobilization nuclease domain-containing protein | - |
HPOKI898_RS05045 | 1078792..1079106 | + | 315 | WP_025276158.1 | hypothetical protein | Antitoxin |
HPOKI898_RS05050 | 1079099..1079380 | + | 282 | WP_015086299.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
HPOKI898_RS05055 | 1079651..1081378 | - | 1728 | WP_025276159.1 | type IV secretory system conjugative DNA transfer family protein | - |
HPOKI898_RS05060 | 1081379..1081936 | - | 558 | WP_025277016.1 | hypothetical protein | - |
HPOKI898_RS05065 | 1081937..1082227 | - | 291 | WP_000159826.1 | hypothetical protein | - |
HPOKI898_RS05070 | 1082224..1082679 | - | 456 | WP_025276161.1 | hypothetical protein | - |
HPOKI898_RS05075 | 1082676..1083617 | - | 942 | WP_025276162.1 | Flp pilus assembly complex ATPase component TadA | - |
HPOKI898_RS05080 | 1083617..1083915 | - | 299 | Protein_974 | hypothetical protein | - |
HPOKI898_RS05085 | 1083912..1084175 | - | 264 | WP_025276164.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Integrative and Conjugative Element | - | - | 1042825..1079654 | 36829 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10860.83 Da Isoelectric Point: 10.0264
>T45643 WP_015086299.1 NZ_CP006827:1079099-1079380 [Helicobacter pylori oki898]
MLKVRTKKDFLKDFNKHILSGRITESDVASVVDCLKKQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK
MLKVRTKKDFLKDFNKHILSGRITESDVASVVDCLKKQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK
Download Length: 282 bp
>T45643 NZ_CP006827:1079099-1079380 [Helicobacter pylori oki898]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATTTTATCTGGGCGTATTACAGAAAGCGA
TGTTGCAAGCGTTGTTGATTGCCTAAAAAAACAAAAACCACTCCAACAAAAATATTGCGACCATGCTTTGAGTGGCAATC
TTAAAGGGCTGAGAGAGTGTCATGTTAAGCCAAACTTGTTATTGATTTATGAAATCAAAAAACAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGCGAGCTATTTAAAAAGTGA
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATTTTATCTGGGCGTATTACAGAAAGCGA
TGTTGCAAGCGTTGTTGATTGCCTAAAAAAACAAAAACCACTCCAACAAAAATATTGCGACCATGCTTTGAGTGGCAATC
TTAAAGGGCTGAGAGAGTGTCATGTTAAGCCAAACTTGTTATTGATTTATGAAATCAAAAAACAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGCGAGCTATTTAAAAAGTGA
Antitoxin
Download Length: 105 a.a. Molecular weight: 12212.73 Da Isoelectric Point: 5.7657
>AT45643 WP_025276158.1 NZ_CP006827:1078792-1079106 [Helicobacter pylori oki898]
MSNIITDYSQYNEKQLHNFLNSIEKQLLKAEGDKNKAIKKIQECELQERMIRQVLAQKHSQEKEPTQSLLNTIVSKDDPE
CDVSFGDFNDFLQIAKQERERRNA
MSNIITDYSQYNEKQLHNFLNSIEKQLLKAEGDKNKAIKKIQECELQERMIRQVLAQKHSQEKEPTQSLLNTIVSKDDPE
CDVSFGDFNDFLQIAKQERERRNA
Download Length: 315 bp
>AT45643 NZ_CP006827:1078792-1079106 [Helicobacter pylori oki898]
ATGTCAAATATTATTACAGATTACTCGCAATACAATGAAAAGCAACTGCACAATTTCTTAAACTCCATTGAAAAACAATT
GCTTAAGGCAGAAGGGGATAAAAATAAGGCGATAAAAAAAATTCAAGAGTGTGAATTGCAAGAACGAATGATCAGACAAG
TTTTAGCCCAAAAACATTCTCAAGAAAAAGAACCCACACAAAGTTTGTTAAATACGATCGTCTCAAAAGATGACCCAGAA
TGCGATGTTTCGTTTGGAGACTTCAATGATTTTTTACAAATAGCAAAACAAGAAAGAGAAAGGCGTAATGCTTAA
ATGTCAAATATTATTACAGATTACTCGCAATACAATGAAAAGCAACTGCACAATTTCTTAAACTCCATTGAAAAACAATT
GCTTAAGGCAGAAGGGGATAAAAATAAGGCGATAAAAAAAATTCAAGAGTGTGAATTGCAAGAACGAATGATCAGACAAG
TTTTAGCCCAAAAACATTCTCAAGAAAAAGAACCCACACAAAGTTTGTTAAATACGATCGTCTCAAAAGATGACCCAGAA
TGCGATGTTTCGTTTGGAGACTTCAATGATTTTTTACAAATAGCAAAACAAGAAAGAGAAAGGCGTAATGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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