Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1534833..1535355 Replicon chromosome
Accession NZ_CP006804
Organism Lactobacillus rhamnosus DSM 14870

Toxin (Protein)


Gene name yoeB Uniprot ID C2JUK2
Locus tag N507_RS07605 Protein ID WP_005687756.1
Coordinates 1535095..1535355 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C2JUK3
Locus tag N507_RS07600 Protein ID WP_005687754.1
Coordinates 1534833..1535102 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N507_RS07580 1530420..1530989 - 570 WP_005687747.1 PTS glucitol/sorbitol transporter subunit IIC -
N507_RS07585 1531002..1531511 - 510 WP_005687749.1 transcriptional regulator GutM -
N507_RS07590 1531512..1533380 - 1869 WP_005687750.1 HTH domain-containing protein -
N507_RS07595 1533407..1534207 - 801 WP_005687752.1 SDR family oxidoreductase -
N507_RS07600 1534833..1535102 + 270 WP_005687754.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
N507_RS07605 1535095..1535355 + 261 WP_005687756.1 Txe/YoeB family addiction module toxin Toxin
N507_RS07610 1535566..1536294 - 729 WP_005687757.1 L-ribulose-5-phosphate 4-epimerase -
N507_RS07615 1536491..1537312 + 822 WP_005687759.1 Cof-type HAD-IIB family hydrolase -
N507_RS07620 1537379..1538266 - 888 WP_005687761.1 L-ribulose-5-phosphate 3-epimerase -
N507_RS07625 1538450..1539229 - 780 WP_005690765.1 DeoR/GlpR family DNA-binding transcription regulator -
N507_RS07630 1539297..1539938 - 642 WP_005687764.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10485.91 Da        Isoelectric Point: 9.6577

>T45626 WP_005687756.1 NZ_CP006804:1535095-1535355 [Lactobacillus rhamnosus DSM 14870]
MIKTWTDDAWADYMYWHDQNDKRTIKRINQLIQAIDRDPYKGIGKPEPLRYALTGKWSRRIDQENRIIYSIEKNHINIFA
CRTHYS

Download         Length: 261 bp

>T45626 NZ_CP006804:1535095-1535355 [Lactobacillus rhamnosus DSM 14870]
ATGATTAAAACCTGGACCGATGATGCTTGGGCGGACTACATGTATTGGCATGATCAAAACGACAAGCGGACAATCAAACG
AATTAATCAACTCATTCAAGCCATTGACCGTGACCCTTATAAAGGCATCGGAAAACCTGAGCCACTTAGATATGCGCTAA
CCGGAAAATGGTCACGTCGGATTGATCAGGAAAATCGCATCATCTACAGCATTGAAAAGAACCACATTAATATTTTCGCC
TGCCGCACTCACTACAGTTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10181.39 Da        Isoelectric Point: 4.6755

>AT45626 WP_005687754.1 NZ_CP006804:1534833-1535102 [Lactobacillus rhamnosus DSM 14870]
MEATNYSDFRRNLKHYMSQVNEDAEPLLVTAKDDDDNVVVMSKHDFDAIEETLYLLSNPKLMAKIKRGDAQIAAGKAKQH
ELLTDFDHD

Download         Length: 270 bp

>AT45626 NZ_CP006804:1534833-1535102 [Lactobacillus rhamnosus DSM 14870]
ATGGAAGCAACGAATTATAGTGATTTCCGCCGCAACCTTAAGCATTATATGAGTCAAGTCAACGAAGACGCCGAACCGCT
ACTGGTTACCGCTAAAGATGATGATGACAATGTGGTGGTTATGAGCAAGCACGATTTTGACGCCATCGAAGAAACCCTGT
ATTTACTCAGCAATCCCAAGCTGATGGCCAAAATCAAACGTGGTGATGCCCAAATTGCCGCTGGAAAGGCTAAACAGCAC
GAGTTGTTAACGGACTTCGATCATGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249N526

Antitoxin

Source ID Structure
AlphaFold DB A0A249N594

References