Detailed information of TA system TA045586

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 2331159..2331853
• Replicon: chromosome
• Accession: NZ_CP006783
• Organism: Yersinia pestis 1412

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: A0A0E1NW62
• Locus tag: M479_RS11995
• Protein ID: WP_002214787.1
• Coordinates: 2331557..2331853 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q666X1
• Locus tag: M479_RS11990
• Protein ID: WP_002209924.1
• Coordinates: 2331159..2331557 (-)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M479_RS11955	2326349..2326714	+	366	WP_002209919.1	hypothetical protein	-
M479_RS11960	2326727..2326963	+	237	WP_002214792.1	hypothetical protein	-
M479_RS11965	2326969..2327301	+	333	WP_002214791.1	hypothetical protein	-
M479_RS11970	2327483..2327683	+	201	WP_002209920.1	AlpA family transcriptional regulator	-
M479_RS24630	2327697..2327849	-	153	WP_002209921.1	hypothetical protein	-
M479_RS11980	2327842..2328168	-	327	WP_002209922.1	type II toxin-antitoxin system RelE/ParE family toxin	-
M479_RS11985	2328468..2330759	+	2292	WP_002209923.1	toprim domain-containing protein	-
M479_RS11990	2331159..2331557	-	399	WP_002209924.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
M479_RS11995	2331557..2331853	-	297	WP_002214787.1	type II toxin-antitoxin system MqsR family toxin	Toxin
M479_RS12000	2332017..2332379	-	363	WP_002209925.1	helix-turn-helix domain-containing protein	-
M479_RS12005	2332442..2332702	-	261	WP_002214785.1	type II toxin-antitoxin system RelE/ParE family toxin	-
M479_RS12015	2333300..2333485	+	186	WP_002209928.1	hypothetical protein	-
M479_RS12020	2333567..2334781	-	1215	WP_011906175.1	tyrosine-type recombinase/integrase	-
M479_RS12030	2335214..2336731	-	1518	WP_002209930.1	lysine--tRNA ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2313309..2339751	26442

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (75-128)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11319.12 Da
• Isoelectric Point: 7.8810

>T45586 WP_002214787.1 NZ_CP006783:c2331853-2331557 [Yersinia pestis 1412]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Nucleotide

• Length: 297 bp

>T45586 NZ_CP006783:c2331853-2331557 [Yersinia pestis 1412]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 14657.17 Da
• Isoelectric Point: 8.4923

>AT45586 WP_002209924.1 NZ_CP006783:c2331557-2331159 [Yersinia pestis 1412]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Nucleotide

• Length: 399 bp

>AT45586 NZ_CP006783:c2331557-2331159 [Yersinia pestis 1412]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Structures

Toxin

• AlphaFold DB: A0A0E1NW62

Antitoxin

• AlphaFold DB: Q666X1