Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3786235..3786929 Replicon chromosome
Accession NZ_CP006758
Organism Yersinia pestis 1522

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag M481_RS18725 Protein ID WP_002214787.1
Coordinates 3786633..3786929 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag M481_RS18720 Protein ID WP_002209924.1
Coordinates 3786235..3786633 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M481_RS18685 3781425..3781790 + 366 WP_002209919.1 hypothetical protein -
M481_RS18690 3781803..3782039 + 237 WP_002214792.1 hypothetical protein -
M481_RS18695 3782045..3782377 + 333 WP_002214791.1 hypothetical protein -
M481_RS18700 3782559..3782759 + 201 WP_002209920.1 AlpA family transcriptional regulator -
M481_RS24625 3782773..3782925 - 153 WP_002209921.1 hypothetical protein -
M481_RS18710 3782918..3783244 - 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
M481_RS18715 3783544..3785835 + 2292 WP_002209923.1 toprim domain-containing protein -
M481_RS18720 3786235..3786633 - 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
M481_RS18725 3786633..3786929 - 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
M481_RS18730 3787093..3787455 - 363 WP_002209925.1 helix-turn-helix domain-containing protein -
M481_RS18735 3787518..3787778 - 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
M481_RS18745 3788376..3788561 + 186 WP_002209928.1 hypothetical protein -
M481_RS18750 3788643..3789857 - 1215 WP_011906175.1 tyrosine-type recombinase/integrase -
M481_RS18760 3790290..3791807 - 1518 WP_002209930.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T45556 WP_002214787.1 NZ_CP006758:c3786929-3786633 [Yersinia pestis 1522]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T45556 NZ_CP006758:c3786929-3786633 [Yersinia pestis 1522]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT45556 WP_002209924.1 NZ_CP006758:c3786633-3786235 [Yersinia pestis 1522]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT45556 NZ_CP006758:c3786633-3786235 [Yersinia pestis 1522]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References