Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2619607..2620301 Replicon chromosome
Accession NZ_CP006754
Organism Yersinia pestis 3067

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag M482_RS13210 Protein ID WP_002214787.1
Coordinates 2619607..2619903 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag M482_RS13215 Protein ID WP_002209924.1
Coordinates 2619903..2620301 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M482_RS13175 2614729..2616246 + 1518 WP_002209930.1 lysine--tRNA ligase -
M482_RS13185 2616679..2617893 + 1215 WP_011906175.1 tyrosine-type recombinase/integrase -
M482_RS13190 2617975..2618160 - 186 WP_002209928.1 hypothetical protein -
M482_RS13200 2618758..2619018 + 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
M482_RS13205 2619081..2619443 + 363 WP_002209925.1 helix-turn-helix domain-containing protein -
M482_RS13210 2619607..2619903 + 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
M482_RS13215 2619903..2620301 + 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
M482_RS13220 2620701..2622992 - 2292 WP_002209923.1 toprim domain-containing protein -
M482_RS13225 2623292..2623618 + 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
M482_RS24555 2623611..2623763 + 153 WP_002209921.1 hypothetical protein -
M482_RS13235 2623777..2623977 - 201 WP_002209920.1 AlpA family transcriptional regulator -
M482_RS13240 2624159..2624491 - 333 WP_002214791.1 hypothetical protein -
M482_RS13245 2624497..2624733 - 237 WP_002214792.1 hypothetical protein -
M482_RS13250 2624746..2625111 - 366 WP_002209919.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T45534 WP_002214787.1 NZ_CP006754:2619607-2619903 [Yersinia pestis 3067]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T45534 NZ_CP006754:2619607-2619903 [Yersinia pestis 3067]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT45534 WP_002209924.1 NZ_CP006754:2619903-2620301 [Yersinia pestis 3067]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT45534 NZ_CP006754:2619903-2620301 [Yersinia pestis 3067]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References