Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2763175..2763869 Replicon chromosome
Accession NZ_CP006751
Organism Yersinia pestis 3770

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag M483_RS13800 Protein ID WP_002214787.1
Coordinates 2763175..2763471 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag M483_RS13805 Protein ID WP_002209924.1
Coordinates 2763471..2763869 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M483_RS13765 2758297..2759814 + 1518 WP_002209930.1 lysine--tRNA ligase -
M483_RS13775 2760247..2761461 + 1215 WP_011906175.1 tyrosine-type recombinase/integrase -
M483_RS13780 2761543..2761728 - 186 WP_002209928.1 hypothetical protein -
M483_RS13790 2762326..2762586 + 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
M483_RS13795 2762649..2763011 + 363 WP_002209925.1 helix-turn-helix domain-containing protein -
M483_RS13800 2763175..2763471 + 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
M483_RS13805 2763471..2763869 + 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
M483_RS13810 2764269..2766560 - 2292 WP_002209923.1 toprim domain-containing protein -
M483_RS13815 2766860..2767186 + 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
M483_RS24540 2767179..2767331 + 153 WP_002209921.1 hypothetical protein -
M483_RS13825 2767345..2767545 - 201 WP_002209920.1 AlpA family transcriptional regulator -
M483_RS13830 2767727..2768059 - 333 WP_002214791.1 hypothetical protein -
M483_RS13835 2768065..2768301 - 237 WP_002214792.1 hypothetical protein -
M483_RS13840 2768314..2768679 - 366 WP_002209919.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T45520 WP_002214787.1 NZ_CP006751:2763175-2763471 [Yersinia pestis 3770]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T45520 NZ_CP006751:2763175-2763471 [Yersinia pestis 3770]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT45520 WP_002209924.1 NZ_CP006751:2763471-2763869 [Yersinia pestis 3770]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT45520 NZ_CP006751:2763471-2763869 [Yersinia pestis 3770]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References