Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1868617..1869311 Replicon chromosome
Accession NZ_CP006748
Organism Yersinia pestis 8787

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag M484_RS09835 Protein ID WP_002214787.1
Coordinates 1869015..1869311 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag M484_RS09830 Protein ID WP_002209924.1
Coordinates 1868617..1869015 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M484_RS09795 1863807..1864172 + 366 WP_002209919.1 hypothetical protein -
M484_RS09800 1864185..1864421 + 237 WP_002214792.1 hypothetical protein -
M484_RS09805 1864427..1864759 + 333 WP_002214791.1 hypothetical protein -
M484_RS09810 1864941..1865141 + 201 WP_002209920.1 AlpA family transcriptional regulator -
M484_RS24330 1865155..1865307 - 153 WP_002209921.1 hypothetical protein -
M484_RS09820 1865300..1865626 - 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
M484_RS09825 1865926..1868217 + 2292 WP_002209923.1 toprim domain-containing protein -
M484_RS09830 1868617..1869015 - 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
M484_RS09835 1869015..1869311 - 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
M484_RS09840 1869475..1869837 - 363 WP_002209925.1 helix-turn-helix domain-containing protein -
M484_RS09845 1869900..1870160 - 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
M484_RS09855 1870758..1870943 + 186 WP_002209928.1 hypothetical protein -
M484_RS09860 1871025..1872239 - 1215 WP_011906175.1 tyrosine-type recombinase/integrase -
M484_RS09870 1872672..1874189 - 1518 WP_002209930.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T45514 WP_002214787.1 NZ_CP006748:c1869311-1869015 [Yersinia pestis 8787]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T45514 NZ_CP006748:c1869311-1869015 [Yersinia pestis 8787]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT45514 WP_002209924.1 NZ_CP006748:c1869015-1868617 [Yersinia pestis 8787]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT45514 NZ_CP006748:c1869015-1868617 [Yersinia pestis 8787]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References