Detailed information of TA system TA045496

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 600533..601239
• Replicon: chromosome
• Accession: NZ_CP006740
• Organism: Xylella fastidiosa MUL0034

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: A0A060HKF7
• Locus tag: P303_RS02730
• Protein ID: WP_038230541.1
• Coordinates: 600937..601239 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q87EE1
• Locus tag: P303_RS02725
• Protein ID: WP_004090697.1
• Coordinates: 600533..600934 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
P303_RS02695	596369..598243	+	1875	WP_040123116.1	phage major capsid protein	-
P303_RS02700	598261..598521	+	261	WP_027700442.1	hypothetical protein	-
P303_RS02705	598521..598844	+	324	WP_027700441.1	hypothetical protein	-
P303_RS02710	598841..599362	+	522	WP_038230165.1	hypothetical protein	-
P303_RS02715	599338..599880	+	543	WP_038230164.1	hypothetical protein	-
P303_RS02720	599877..600464	+	588	WP_040123117.1	phage baseplate assembly protein V	-
P303_RS02725	600533..600934	-	402	WP_004090697.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
P303_RS02730	600937..601239	-	303	WP_038230541.1	type II toxin-antitoxin system MqsR family toxin	Toxin
P303_RS02735	601327..601602	-	276	WP_004085172.1	HigA family addiction module antidote protein	-
P303_RS02740	601613..601894	-	282	WP_004085174.1	type II toxin-antitoxin system RelE/ParE family toxin	-
P303_RS02745	602092..602430	+	339	WP_038210500.1	GPW/gp25 family protein	-
P303_RS02750	602430..603323	+	894	WP_040123118.1	baseplate J/gp47 family protein	-
P303_RS02755	603316..603873	+	558	WP_040123345.1	phage tail protein I	-
P303_RS02760	603881..605473	+	1593	WP_040123119.1	tail fiber domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	570706..618044	47338

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-99)

Antitoxin

• Cro/C1-type helix-turn-helix domain (74-127)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 10972.77 Da
• Isoelectric Point: 8.0251

>T45496 WP_038230541.1 NZ_CP006740:c601239-600937 [Xylella fastidiosa MUL0034]
MEKGTPHYKLPVVKALVKAGKVRATATAYQGARELGIKDLTGMCAVVLALTSADFYKSMTTYTDHTLFQDVYHAKTASGD
EVYLKLTVIDDVLIVSFKEL

Nucleotide

• Length: 303 bp

>T45496 NZ_CP006740:c601239-600937 [Xylella fastidiosa MUL0034]
ATGGAGAAAGGCACACCCCACTACAAGCTACCAGTCGTCAAAGCCTTGGTGAAAGCTGGCAAGGTCAGGGCTACAGCGAC
CGCCTACCAAGGAGCACGTGAGCTTGGCATCAAAGATTTAACTGGAATGTGCGCCGTTGTCTTGGCGCTCACGTCTGCCG
ACTTCTACAAGAGTATGACGACCTACACGGATCACACATTATTCCAGGATGTGTACCACGCCAAGACGGCAAGCGGTGAT
GAGGTGTACCTGAAGTTAACTGTCATTGATGACGTGTTGATTGTTTCCTTCAAGGAGTTATGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14944.02 Da
• Isoelectric Point: 7.1650

>AT45496 WP_004090697.1 NZ_CP006740:c600934-600533 [Xylella fastidiosa MUL0034]
MRCPCCGAAELIHDTRDMLYTYKSETTSIPTVTGDFCPACGEVVLDREHGDRYSELVGLFQRQVNSAYVDPGYITKVRRK
LDLDQRQAAELFGGGVNAFSRYENGKTKPPLSLVKLFKLLDRHPDLLNEVKSS

Nucleotide

• Length: 402 bp

>AT45496 NZ_CP006740:c600934-600533 [Xylella fastidiosa MUL0034]
ATGAGATGCCCATGCTGCGGCGCGGCAGAACTGATCCACGACACGCGCGACATGCTTTACACCTACAAGAGCGAAACTAC
CAGTATCCCAACGGTGACCGGCGACTTCTGCCCGGCTTGTGGCGAAGTCGTCTTGGACCGTGAACATGGTGATCGTTACA
GCGAATTGGTCGGCCTGTTCCAACGTCAGGTGAATTCGGCCTACGTCGATCCTGGTTACATTACCAAGGTACGCCGGAAG
CTTGATCTCGACCAGCGGCAAGCTGCCGAACTGTTCGGTGGTGGTGTTAATGCTTTCTCACGTTACGAGAATGGTAAAAC
CAAGCCGCCGCTGTCTTTGGTTAAGTTATTCAAGCTTCTGGATCGCCACCCCGATTTGCTCAACGAAGTGAAGAGTTCCT
AA

Structures

Toxin

• AlphaFold DB: A0A060HKF7

Antitoxin

• AlphaFold DB: Q87EE1