Detailed information of TA system TA045290

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2198617..2198880
• Replicon: chromosome
• Accession: NZ_CP006630
• Organism: Staphylococcus aureus subsp. aureus SA268

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: SA268_RS11135
• Protein ID: WP_001802298.1
• Coordinates: 2198776..2198880 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2198617..2198781 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SA268_RS11115	2194854..2195519	-	666	WP_001024088.1	SDR family oxidoreductase	-
SA268_RS11120	2195671..2195991	+	321	WP_000139802.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
SA268_RS11125	2195993..2196970	+	978	WP_000019732.1	CDF family zinc efflux transporter CzrB	-
SA268_RS11130	2197236..2198327	+	1092	WP_000495695.1	hypothetical protein	-
-	2198617..2198781	+	165	-	-	Antitoxin
SA268_RS11135	2198776..2198880	-	105	WP_001802298.1	hypothetical protein	Toxin
SA268_RS15330	2199041..2199524	-	484	Protein_2112	recombinase family protein	-
SA268_RS14995	2199567..2200703	-	1137	Protein_2113	SAP domain-containing protein	-
SA268_RS11155	2200992..2201084	+	93	WP_031844941.1	hypothetical protein	-
SA268_RS11160	2201779..2202636	-	858	WP_000370919.1	Cof-type HAD-IIB family hydrolase	-
SA268_RS11165	2202704..2203486	-	783	WP_000908190.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T45290 WP_001802298.1 NZ_CP006630:c2198880-2198776 [Staphylococcus aureus subsp. aureus SA268]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T45290 NZ_CP006630:c2198880-2198776 [Staphylococcus aureus subsp. aureus SA268]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 165 bp

>AT45290 NZ_CP006630:2198617-2198781 [Staphylococcus aureus subsp. aureus SA268]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin