Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/- |
| Location | 1927574..1927988 | Replicon | chromosome |
| Accession | NZ_CP006630 | ||
| Organism | Staphylococcus aureus subsp. aureus SA268 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | SA268_RS09490 | Protein ID | WP_001065099.1 |
| Coordinates | 1927737..1927988 (-) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | SA268_RS15415 | Protein ID | WP_000028424.1 |
| Coordinates | 1927574..1927747 (-) | Length | 58 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SA268_RS09440 | 1923074..1924297 | - | 1224 | WP_001037578.1 | PBSX family phage terminase large subunit | - |
| SA268_RS09445 | 1924290..1924784 | - | 495 | WP_000594088.1 | terminase small subunit | - |
| SA268_RS09455 | 1925139..1925540 | - | 402 | WP_000286968.1 | hypothetical protein | - |
| SA268_RS09460 | 1925541..1925714 | - | 174 | WP_000595257.1 | transcriptional activator RinB | - |
| SA268_RS09465 | 1925727..1926185 | - | 459 | WP_001129214.1 | hypothetical protein | - |
| SA268_RS15290 | 1926178..1926330 | - | 153 | WP_038412600.1 | DUF1381 domain-containing protein | - |
| SA268_RS09475 | 1926327..1926572 | - | 246 | WP_001282074.1 | hypothetical protein | - |
| SA268_RS09480 | 1926609..1927115 | - | 507 | WP_001061834.1 | dUTPase | - |
| SA268_RS15410 | 1927130..1927291 | - | 162 | WP_000889683.1 | hypothetical protein | - |
| SA268_RS09485 | 1927292..1927573 | - | 282 | WP_000454994.1 | hypothetical protein | - |
| SA268_RS15415 | 1927574..1927747 | - | 174 | WP_000028424.1 | hypothetical protein | Antitoxin |
| SA268_RS09490 | 1927737..1927988 | - | 252 | WP_001065099.1 | DUF1024 family protein | Toxin |
| SA268_RS09495 | 1928003..1928245 | - | 243 | WP_000131388.1 | phi PVL orf 51-like protein | - |
| SA268_RS09500 | 1928249..1928605 | - | 357 | WP_000029366.1 | hypothetical protein | - |
| SA268_RS09505 | 1928606..1928791 | - | 186 | WP_001187236.1 | DUF3113 family protein | - |
| SA268_RS09510 | 1928796..1929200 | - | 405 | WP_021758092.1 | DUF1064 domain-containing protein | - |
| SA268_RS09515 | 1929197..1929622 | - | 426 | WP_000451862.1 | DNA N-6-adenine-methyltransferase | - |
| SA268_RS09520 | 1929632..1929853 | - | 222 | WP_001123688.1 | DUF3269 family protein | - |
| SA268_RS15420 | 1929866..1930027 | - | 162 | WP_000237153.1 | hypothetical protein | - |
| SA268_RS09530 | 1930021..1930800 | - | 780 | WP_038412603.1 | ATP-binding protein | - |
| SA268_RS09535 | 1930810..1931580 | - | 771 | WP_000190224.1 | conserved phage C-terminal domain-containing protein | - |
| SA268_RS09540 | 1931645..1932502 | + | 858 | WP_000371250.1 | DUF4393 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | scn / chp | 1889218..1942270 | 53052 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9376.32 Da Isoelectric Point: 3.8364
>T45285 WP_001065099.1 NZ_CP006630:c1927988-1927737 [Staphylococcus aureus subsp. aureus SA268]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILKGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILKGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY
Download Length: 252 bp
>T45285 NZ_CP006630:c1927988-1927737 [Staphylococcus aureus subsp. aureus SA268]
ATGAATAACCGCGAACAAATTGAACAGTCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTAAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG
ATGAATAACCGCGAACAAATTGAACAGTCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTAAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG
Antitoxin
Download Length: 58 a.a. Molecular weight: 6468.29 Da Isoelectric Point: 4.2484
>AT45285 WP_000028424.1 NZ_CP006630:c1927747-1927574 [Staphylococcus aureus subsp. aureus SA268]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
Download Length: 174 bp
>AT45285 NZ_CP006630:c1927747-1927574 [Staphylococcus aureus subsp. aureus SA268]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|