Detailed information of TA system TA045091

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2716089..2716749
• Replicon: chromosome
• Accession: NZ_CP005927
• Organism: Serratia sp. FS14

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: L085_RS12340
• Protein ID: WP_015378478.1
• Coordinates: 2716089..2716442 (+)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A6G8TPX9
• Locus tag: L085_RS12345
• Protein ID: WP_004935502.1
• Coordinates: 2716447..2716749 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L085_RS12320	2712180..2712545	+	366	WP_004935528.1	diacylglycerol kinase	-
L085_RS12325	2712649..2713548	+	900	WP_044030852.1	LysR family transcriptional regulator	-
L085_RS12330	2713523..2714329	-	807	WP_044030853.1	substrate-binding domain-containing protein	-
L085_RS12335	2714356..2715651	-	1296	WP_044030854.1	MFS transporter	-
L085_RS12340	2716089..2716442	+	354	WP_015378478.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L085_RS12345	2716447..2716749	+	303	WP_004935502.1	XRE family transcriptional regulator	Antitoxin
L085_RS12350	2717175..2718383	+	1209	WP_044030855.1	aldose 1-epimerase family protein	-
L085_RS12360	2718979..2720097	+	1119	WP_033632602.1	branched-chain amino acid ABC transporter substrate-binding protein	-
L085_RS12365	2720222..2721136	+	915	WP_044030856.1	branched-chain amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-79)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13595.58 Da
• Isoelectric Point: 9.0493

>T45091 WP_015378478.1 NZ_CP005927:2716089-2716442 [Serratia sp. FS14]
VWEIKTTDAFDHWFRSLSDADRACVLAALMVLREKGPGLPRPYADTVKGSRYSNMKELRIQSRGEPLRAFFAFDPYRVGM
VLCAGNKAGDEKRFYDRMLQIADREFTNWLNTLKEKE

Nucleotide

• Length: 354 bp

>T45091 NZ_CP005927:2716089-2716442 [Serratia sp. FS14]
GTGTGGGAAATTAAAACAACGGATGCATTTGATCATTGGTTCAGATCACTCAGCGATGCCGACCGGGCCTGCGTGCTTGC
TGCATTGATGGTCCTGCGGGAAAAAGGGCCCGGCTTGCCCAGACCCTATGCCGATACGGTTAAAGGCTCGCGTTACAGCA
ACATGAAAGAGCTGCGTATTCAGAGCCGTGGCGAACCGTTGCGGGCATTCTTCGCCTTCGATCCGTACCGCGTCGGCATG
GTGCTTTGCGCGGGCAATAAAGCGGGCGATGAAAAACGTTTTTACGATCGAATGCTGCAGATTGCCGATCGGGAATTCAC
GAATTGGCTGAACACACTAAAAGAGAAGGAGTGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11142.96 Da
• Isoelectric Point: 5.1992

>AT45091 WP_004935502.1 NZ_CP005927:2716447-2716749 [Serratia sp. FS14]
MGRTLEQLIAEEKPEVVAEAQAMATDIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Nucleotide

• Length: 303 bp

>AT45091 NZ_CP005927:2716447-2716749 [Serratia sp. FS14]
ATGGGCAGAACGCTGGAACAGCTTATTGCGGAGGAAAAGCCCGAGGTCGTGGCCGAAGCGCAGGCAATGGCGACGGACAT
TATGCTGAACATCCATCTTGCCGAGCTGCGCGAGAAGGTGCAGAAAACCCAGGTTGAAATGGCGCAGGCGCTGGGTATCC
GGCAACCGACCGTCGCCGTGATGGAAAAACCGGGCCGCGATCTGAAACTGTCTTCGCTTAAACGCTATGTTGAGGCGGCC
GGCGGCAAACTGCGCCTGGATGTCGAACTGCCGGACGGTTCGCACTACGAATTTGTGCTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A6G8TPX9