Detailed information of TA system TA045088

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1968669..1969321
• Replicon: chromosome
• Accession: NZ_CP005927
• Organism: Serratia sp. FS14

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: L085_RS08910
• Protein ID: WP_004931830.1
• Coordinates: 1968977..1969321 (-)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A086GAN0
• Locus tag: L085_RS08905
• Protein ID: WP_004931828.1
• Coordinates: 1968669..1968971 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L085_RS08880	1963677..1964324	-	648	WP_004931818.1	DsbA family protein	-
L085_RS08885	1964393..1965277	-	885	WP_044030591.1	MBL fold metallo-hydrolase	-
L085_RS08890	1965386..1966294	+	909	WP_015378928.1	LysR family transcriptional regulator	-
L085_RS08895	1966322..1967245	-	924	WP_021505677.1	LysR family transcriptional regulator	-
L085_RS08900	1967379..1968641	+	1263	WP_044030592.1	diaminopimelate decarboxylase	-
L085_RS08905	1968669..1968971	-	303	WP_004931828.1	helix-turn-helix transcriptional regulator	Antitoxin
L085_RS08910	1968977..1969321	-	345	WP_004931830.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L085_RS08915	1969481..1970500	-	1020	WP_004931832.1	HTH-type transcriptional regulator GalR	-
L085_RS08920	1970722..1972980	+	2259	WP_044030593.1	molybdopterin guanine dinucleotide-containing S/N-oxide reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (32-85)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 13383.44 Da
• Isoelectric Point: 10.6087

>T45088 WP_004931830.1 NZ_CP005927:c1969321-1968977 [Serratia sp. FS14]
MWQVVTVERFDDWFLALNNAQQTSILAAIYKLQTFGPQLARPHADTLHFSDAVRQLKELRIQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDKRFYQRMLPIAAMEFSHYLATRR

Nucleotide

• Length: 345 bp

>T45088 NZ_CP005927:c1969321-1968977 [Serratia sp. FS14]
ATGTGGCAAGTGGTGACCGTCGAACGGTTTGACGACTGGTTTTTGGCGCTCAACAACGCCCAGCAAACAAGCATCCTGGC
GGCGATCTACAAATTGCAGACGTTCGGTCCGCAATTGGCGCGGCCGCATGCCGATACGCTGCATTTTTCCGACGCGGTCC
GGCAGTTGAAGGAGCTGCGCATTCAACATCGCGGGCGCCCTTTCAGGGTGTTTTTCGCCTTTGATCCACAGCGGCAAGCG
GTATTGCTGTGCGGCGGCGATAAAACCGGCGACAAACGCTTTTACCAGCGCATGTTGCCCATCGCCGCCATGGAGTTTTC
ACATTATCTGGCAACCCGGAGGTAG

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11080.97 Da
• Isoelectric Point: 10.1998

>AT45088 WP_004931828.1 NZ_CP005927:c1968971-1968669 [Serratia sp. FS14]
MAKPLSQLIDKLDPAVVAAARQKADQEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Nucleotide

• Length: 303 bp

>AT45088 NZ_CP005927:c1968971-1968669 [Serratia sp. FS14]
ATGGCCAAACCTTTATCCCAACTGATCGATAAACTCGATCCCGCCGTCGTTGCCGCCGCCAGGCAAAAAGCGGACCAGGA
GATTTTCGAGCTGCGGCTGGCGATGCTGAGGGAAGAGTTGGCGGTTTCTCAGGTTGAATTGGCGAAGCGGCTCGGCATCA
GCCAACCCTCCGTCGCCAATTTGGAAAAGCGCGGCAGCGAAATCAAACTGTCGTCGCTCAAACGCTATATCGAGGCGATG
GGCGGCACGCTGTCGCTGGATGTGCAATTGCCCAATGGCCAGCACCGCCGCATGACGCTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A086GAN0