Detailed information of TA system TA045086

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1508818..1509446
• Replicon: chromosome
• Accession: NZ_CP005927
• Organism: Serratia sp. FS14

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: L085_RS06950
• Protein ID: WP_044030403.1
• Coordinates: 1509156..1509446 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A8B4GQY7
• Locus tag: L085_RS06945
• Protein ID: WP_015379150.1
• Coordinates: 1508818..1509141 (-)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L085_RS06920	1503830..1505065	-	1236	WP_004937146.1	serine/threonine transporter SstT	-
L085_RS06925	1505328..1506293	-	966	WP_004937148.1	TerC family protein	-
L085_RS06930	1506549..1507280	-	732	WP_004937150.1	glutamine amidotransferase	-
L085_RS06935	1507282..1508262	-	981	WP_004937152.1	Gfo/Idh/MocA family oxidoreductase	-
L085_RS06940	1508313..1508825	-	513	WP_016930176.1	M48 family metallopeptidase	-
L085_RS06945	1508818..1509141	-	324	WP_015379150.1	HigA family addiction module antidote protein	Antitoxin
L085_RS06950	1509156..1509446	-	291	WP_044030403.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L085_RS06955	1509677..1510816	+	1140	WP_044030404.1	23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG	-
L085_RS06960	1511012..1513033	-	2022	WP_044030406.1	NADPH-dependent 2,4-dienoyl-CoA reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (1-94)

Antitoxin

• Cro/C1-type helix-turn-helix domain (24-71)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11599.25 Da
• Isoelectric Point: 10.0175

>T45086 WP_044030403.1 NZ_CP005927:c1509446-1509156 [Serratia sp. FS14]
MIKSFRDRYLEQFYLEGKRSRLIPGVLERQLARKLDILAAAQQERDLHHPTGNYYKRLSGPFQGWSSLRVNMHWQLMFQW
RHDAAEKIYLDPHQDT

Nucleotide

• Length: 291 bp

>T45086 NZ_CP005927:c1509446-1509156 [Serratia sp. FS14]
ATGATTAAATCTTTCCGCGATCGCTATCTGGAGCAGTTCTATCTGGAAGGCAAACGCAGCCGTCTGATCCCCGGCGTGCT
CGAGCGGCAGTTGGCCAGAAAGCTCGATATATTGGCCGCCGCGCAGCAAGAGCGTGATTTGCATCACCCCACGGGTAACT
ATTACAAGCGGCTATCCGGGCCATTTCAGGGATGGTCAAGTCTGCGCGTCAATATGCACTGGCAGCTGATGTTCCAGTGG
CGGCATGATGCCGCTGAAAAAATTTACCTCGATCCTCACCAAGATACCTGA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12141.78 Da
• Isoelectric Point: 6.2285

>AT45086 WP_015379150.1 NZ_CP005927:c1509141-1508818 [Serratia sp. FS14]
MLETTTREPTTVGEVLQEEYLTPLGIGQEELAKVLGVTRATVNRLCNGHRRMSVAEANLFADLFETTADFWLNLQAAHDR
WEARQADAQRVRLRPIKEILGRNITHA

Nucleotide

• Length: 324 bp

>AT45086 NZ_CP005927:c1509141-1508818 [Serratia sp. FS14]
ATGTTGGAAACCACGACTCGCGAACCCACCACGGTGGGGGAAGTGCTGCAGGAAGAGTATTTAACGCCGTTGGGCATCGG
CCAGGAAGAACTGGCGAAGGTACTGGGCGTCACCCGTGCCACTGTTAACCGCCTGTGCAACGGGCATCGACGCATGAGCG
TTGCCGAGGCCAACCTGTTTGCCGACCTGTTCGAAACGACCGCCGACTTTTGGCTAAACCTGCAGGCGGCACACGATCGC
TGGGAAGCCAGACAGGCCGATGCGCAACGTGTGCGGCTGCGGCCAATCAAAGAAATACTGGGACGCAATATCACTCATGC
ATGA

Structures

Antitoxin

• AlphaFold DB: A0A8B4GQY7