Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2538700..2539282 Replicon chromosome
Accession NZ_CP005188
Organism Sphingobium sp. MI1205

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag K663_RS12435 Protein ID WP_062118016.1
Coordinates 2539001..2539282 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K663_RS12430 Protein ID WP_145902338.1
Coordinates 2538700..2538981 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K663_RS12405 2534086..2535387 + 1302 WP_062118009.1 sugar MFS transporter -
K663_RS12410 2535410..2536303 - 894 WP_062120852.1 N-formylglutamate amidohydrolase -
K663_RS12415 2536452..2536829 + 378 WP_062120855.1 response regulator -
K663_RS12425 2537564..2538601 + 1038 WP_062118011.1 site-specific integrase -
K663_RS12430 2538700..2538981 - 282 WP_145902338.1 HigA family addiction module antidote protein Antitoxin
K663_RS12435 2539001..2539282 - 282 WP_062118016.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K663_RS12440 2539555..2539926 + 372 WP_062118019.1 type II toxin-antitoxin system VapC family toxin -
K663_RS12445 2540090..2541208 - 1119 WP_062118022.1 Fic family protein -
K663_RS12450 2541360..2542387 - 1028 Protein_2467 HipA domain-containing protein -
K663_RS12455 2542684..2542911 + 228 WP_062118025.1 transcriptional regulator -
K663_RS12460 2542915..2543295 + 381 WP_062118028.1 type II toxin-antitoxin system death-on-curing family toxin -
K663_RS12465 2543665..2544063 + 399 WP_062118031.1 DUF2384 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-78)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10357.88 Da        Isoelectric Point: 7.1670

>T45078 WP_062118016.1 NZ_CP005188:c2539282-2539001 [Sphingobium sp. MI1205]
MIQSVKGKLMEQVLAGKAGKGFPSDLFRVAVRKVAMLEASIKLDDLRVPPANRLEALSGDRAGQHSIRINDQWRICFTWS
DNGPENVEIVDDH

Download         Length: 282 bp

>T45078 NZ_CP005188:c2539282-2539001 [Sphingobium sp. MI1205]
ATGATACAGAGCGTTAAAGGGAAGCTGATGGAGCAGGTGCTCGCCGGTAAGGCGGGCAAGGGCTTCCCGTCCGATTTGTT
TCGGGTTGCTGTCCGCAAAGTCGCCATGTTGGAAGCTTCTATAAAGCTGGACGATCTCCGTGTTCCACCAGCCAACCGAC
TAGAAGCTCTTTCCGGCGACAGAGCAGGGCAACATTCGATTCGGATCAACGACCAGTGGCGCATCTGTTTCACTTGGTCC
GATAATGGCCCGGAAAATGTTGAAATCGTGGACGACCATTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10358.00 Da        Isoelectric Point: 5.5134

>AT45078 WP_145902338.1 NZ_CP005188:c2538981-2538700 [Sphingobium sp. MI1205]
MLQVPVHPGEILKHEFLEEMGISAGKLAKHIHVPRTRIERLCAEETSVTTDTAMRLARALGTTAEFWLNLQAHYDLLVTD
AADIKEIEPLLAA

Download         Length: 282 bp

>AT45078 NZ_CP005188:c2538981-2538700 [Sphingobium sp. MI1205]
ATGCTGCAAGTGCCGGTCCATCCCGGCGAAATCCTGAAGCATGAATTTTTGGAGGAAATGGGTATTAGCGCGGGGAAGCT
GGCAAAGCATATCCATGTACCCCGCACGCGGATCGAGCGCCTATGTGCGGAGGAGACTTCCGTCACCACTGATACCGCTA
TGCGGCTGGCGCGGGCGCTGGGCACGACCGCAGAGTTCTGGCTAAACCTTCAGGCGCATTATGACCTACTGGTGACGGAC
GCAGCGGACATAAAGGAAATAGAGCCGCTGCTTGCAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References