Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3790915..3791600 Replicon chromosome
Accession NZ_CP005083
Organism Sphingobium sp. TKS

Toxin (Protein)


Gene name higB Uniprot ID A0A126RRH5
Locus tag K426_RS18760 Protein ID WP_066560434.1
Coordinates 3791238..3791600 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A126RR18
Locus tag K426_RS18755 Protein ID WP_066560426.1
Coordinates 3790915..3791235 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K426_RS18735 3786454..3787158 - 705 WP_066560403.1 hypothetical protein -
K426_RS18740 3787168..3790164 - 2997 WP_066560408.1 Ti-type conjugative transfer relaxase TraA -
K426_RS18745 3790336..3790641 + 306 WP_066562018.1 conjugal transfer protein TraD -
K426_RS18750 3790679..3790924 + 246 WP_066560417.1 conjugal transfer protein TraD -
K426_RS18755 3790915..3791235 - 321 WP_066560426.1 XRE family transcriptional regulator Antitoxin
K426_RS18760 3791238..3791600 - 363 WP_066560434.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K426_RS18765 3792152..3792355 + 204 WP_066560436.1 AlpA family phage regulatory protein -
K426_RS18770 3792368..3793600 - 1233 WP_066560438.1 tyrosine-type recombinase/integrase -
K426_RS31830 3794126..3794716 + 591 WP_051585559.1 hypothetical protein -
K426_RS18780 3794901..3795881 + 981 WP_021688198.1 toprim domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3785176..3795881 10705


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-108)

Antitoxin

HigA2-like, helix-turn-helix domain

(8-89)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13308.13 Da        Isoelectric Point: 6.8818

>T45068 WP_066560434.1 NZ_CP005083:c3791600-3791238 [Sphingobium sp. TKS]
MPWTVRNHDAFDAEYDAMPDAVQDELLAATGLLELYGPRLGRPHADTLGGSRHANMKELRFNADGGVWRVAFAFDPERQA
ILLVAGDKAGVAQKRFYKTLIAKADKRFDEHLAALAAKEK

Download         Length: 363 bp

>T45068 NZ_CP005083:c3791600-3791238 [Sphingobium sp. TKS]
ATGCCGTGGACGGTTCGCAACCATGATGCCTTCGACGCTGAATATGACGCGATGCCCGATGCGGTGCAGGACGAACTTTT
GGCGGCAACCGGCCTATTGGAACTTTACGGTCCCCGGCTTGGTCGCCCCCATGCCGATACGCTTGGCGGATCGCGGCACG
CGAACATGAAGGAATTGCGCTTCAATGCCGATGGCGGTGTATGGCGCGTGGCTTTTGCGTTCGACCCGGAGCGGCAAGCG
ATCCTGCTGGTTGCGGGCGACAAGGCAGGCGTGGCGCAGAAGCGGTTTTACAAGACGTTGATTGCCAAGGCCGACAAGCG
GTTTGACGAGCATCTGGCGGCGCTGGCCGCGAAGGAGAAATGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11835.62 Da        Isoelectric Point: 9.9148

>AT45068 WP_066560426.1 NZ_CP005083:c3791235-3790915 [Sphingobium sp. TKS]
MGRSRSEIMAALPEDRRRRIEARAQELVAEVEGLKALRQLAERSQEQIAETLGVKQPSVHKIERQTDLYLSTLRRFVEAA
GGKLELRVELPGKGVLHLTGVGDLHA

Download         Length: 321 bp

>AT45068 NZ_CP005083:c3791235-3790915 [Sphingobium sp. TKS]
ATGGGACGTTCGCGCAGTGAGATCATGGCCGCCCTGCCCGAAGATCGCCGCCGCCGCATCGAGGCGCGCGCGCAGGAATT
GGTTGCGGAGGTCGAGGGACTAAAAGCGTTACGCCAGCTTGCCGAGCGCAGCCAAGAACAGATCGCGGAAACCTTGGGCG
TGAAGCAGCCTTCCGTTCACAAGATCGAGCGACAGACGGACCTTTACCTTTCGACGCTTCGCCGCTTCGTTGAGGCAGCG
GGCGGCAAGCTGGAACTTCGCGTCGAATTGCCCGGCAAAGGCGTCCTGCATCTGACGGGTGTTGGCGATCTTCACGCCTG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126RRH5

Antitoxin

Source ID Structure
AlphaFold DB A0A126RR18

References