Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 701536..702053 Replicon chromosome
Accession NZ_CP005083
Organism Sphingobium sp. TKS

Toxin (Protein)


Gene name yoeB Uniprot ID A0A126RHY0
Locus tag K426_RS03660 Protein ID WP_066553894.1
Coordinates 701787..702053 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A126RHK8
Locus tag K426_RS03655 Protein ID WP_066553891.1
Coordinates 701536..701790 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K426_RS03625 697387..697668 - 282 WP_066561320.1 helix-turn-helix domain-containing protein -
K426_RS03630 697806..698333 - 528 WP_066553880.1 DUF2285 domain-containing protein -
K426_RS03635 698686..698952 - 267 WP_066561322.1 DUF2285 domain-containing protein -
K426_RS03640 699073..699327 - 255 WP_066553882.1 helix-turn-helix transcriptional regulator -
K426_RS03645 699524..699850 - 327 WP_066553885.1 DUF736 domain-containing protein -
K426_RS03650 700427..700867 - 441 WP_066553888.1 hypothetical protein -
K426_RS32075 701009..701173 - 165 WP_197672757.1 hypothetical protein -
K426_RS03655 701536..701790 + 255 WP_066553891.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
K426_RS03660 701787..702053 + 267 WP_066553894.1 Txe/YoeB family addiction module toxin Toxin
K426_RS03665 702319..703329 + 1011 WP_066561324.1 sodium:calcium antiporter -
K426_RS03670 703376..704302 - 927 WP_066561327.1 DUF2493 domain-containing protein -
K426_RS03675 704608..705642 - 1035 WP_145907176.1 toprim domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 560094..729888 169794


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-70)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10309.77 Da        Isoelectric Point: 8.5042

>T45066 WP_066553894.1 NZ_CP005083:701787-702053 [Sphingobium sp. TKS]
VKLVFADSAWEDYLHWQANAPNILQRVNDLIKECQRAPFKGTGKPEPLKGDLKGWWSRRITLEDRLVYRVTGSPPDQQLE
IAQCRFHY

Download         Length: 267 bp

>T45066 NZ_CP005083:701787-702053 [Sphingobium sp. TKS]
GTGAAGCTCGTCTTCGCCGACTCGGCTTGGGAAGATTATCTCCATTGGCAGGCCAATGCTCCCAACATTCTGCAACGCGT
CAACGATCTCATCAAGGAATGCCAGCGCGCTCCCTTCAAGGGCACGGGGAAACCCGAGCCGCTGAAGGGCGACCTCAAAG
GCTGGTGGTCGAGGCGCATCACGCTGGAAGACAGGCTCGTCTATCGGGTCACGGGTAGCCCACCGGATCAACAGCTCGAA
ATCGCGCAATGTCGTTTCCACTATTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9238.55 Da        Isoelectric Point: 5.0760

>AT45066 WP_066553891.1 NZ_CP005083:701536-701790 [Sphingobium sp. TKS]
MDVISYSDTRAHLKEVMDRVVADRAPVVVSRQKAESVVMISLSDWNAIEESMHLLSTEANRKRLMAAIGQLEGGNGKASD
LIEP

Download         Length: 255 bp

>AT45066 NZ_CP005083:701536-701790 [Sphingobium sp. TKS]
ATGGACGTGATCAGCTATTCCGATACCCGCGCGCACCTGAAAGAGGTGATGGACCGTGTTGTCGCGGATCGCGCTCCTGT
GGTTGTATCGCGCCAGAAGGCGGAATCCGTGGTGATGATCTCGCTTTCGGATTGGAACGCGATCGAGGAATCGATGCACT
TACTTTCCACCGAGGCCAACAGGAAGCGCCTGATGGCGGCCATCGGACAGTTGGAAGGCGGCAATGGCAAAGCCAGTGAT
CTGATCGAACCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126RHY0

Antitoxin

Source ID Structure
AlphaFold DB A0A126RHK8

References