Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 746680..747330 Replicon chromosome
Accession NZ_CP004887
Organism Klebsiella michiganensis HKOPL1

Toxin (Protein)


Gene name higB Uniprot ID A0A0H3H3K0
Locus tag J415_RS03465 Protein ID WP_014227314.1
Coordinates 746680..747021 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0H3H3Q5
Locus tag J415_RS03470 Protein ID WP_014227313.1
Coordinates 747031..747330 (+) Length 100 a.a.

Genomic Context

J415_RS03450J415_RS03455J415_RS03460J415_RS03465J415_RS03470J415_RS03475J415_RS03490J415_RS03480J415_RS03485
Location: 742672..743991 (1320 bp)
Type: Others
Protein ID: WP_014227316.1
Location: 744137..745528 (1392 bp)
Type: Others
Protein ID: WP_014227315.1
Location: 745977..746429 (453 bp)
Type: Others
Protein ID: WP_009653860.1
Location: 746680..747021 (342 bp)
Type: Toxin
Protein ID: WP_014227314.1
Location: 747031..747330 (300 bp)
Type: Antitoxin
Protein ID: WP_014227313.1
Location: 747449..748630 (1182 bp)
Type: Others
Protein ID: WP_014227312.1
Location: 750726..751445 (720 bp)
Type: Others
Protein ID: WP_014227309.1
Location: 748663..749472 (810 bp)
Type: Others
Protein ID: WP_038422921.1
Location: 749482..750585 (1104 bp)
Type: Others
Protein ID: WP_014227310.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
J415_RS03450742672..743991+1320WP_014227316.1MFS transporter-
J415_RS03455744137..745528+1392WP_014227315.1hexose-6-phosphate:phosphate antiporter-
J415_RS03460745977..746429+453WP_009653860.1DUF1198 domain-containing protein-
J415_RS03465746680..747021+342WP_014227314.1type II toxin-antitoxin system RelE/ParE family toxinToxin
J415_RS03470747031..747330+300WP_014227313.1helix-turn-helix transcriptional regulatorAntitoxin
J415_RS03475747449..748630+1182WP_014227312.1purine ribonucleoside efflux pump NepI-
J415_RS03480748663..749472-810WP_038422921.1phosphonoacetaldehyde hydrolase-
J415_RS03485749482..750585-1104WP_014227310.12-aminoethylphosphonate--pyruvate transaminase-
J415_RS03490750726..751445+720WP_014227309.1phosphonate utilization transcriptional regulator PhnR-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13110.00 Da        Isoelectric Point: 5.7545

>T45047 WP_014227314.1 NZ_CP004887:746680-747021 [Klebsiella michiganensis HKOPL1]
MWDVETTEVFDKWFEAQTEALKEDMLAAMVILSEYGPRLGRPFADTVNDSAFSNMKELRIQHQGRPIRAFFVFDPSRCGI
VLCAGDKTGLNEKRFYKDMIKLADAEYRKHLNQ

Download         Length: 342 bp

>T45047 NZ_CP004887:746680-747021 [Klebsiella michiganensis HKOPL1]
ATGTGGGATGTTGAAACAACGGAGGTTTTTGACAAGTGGTTTGAGGCGCAGACCGAAGCGCTCAAAGAGGATATGCTCGC
CGCAATGGTGATCTTATCCGAGTATGGCCCCCGGTTGGGAAGGCCGTTTGCGGATACAGTAAACGATTCTGCCTTTTCGA
ATATGAAAGAGCTGCGCATTCAGCATCAAGGTAGACCCATCCGAGCTTTCTTTGTATTTGACCCTTCTCGTTGTGGCATC
GTGTTATGCGCCGGAGATAAAACAGGGTTAAATGAAAAGAGATTCTATAAAGATATGATCAAGCTTGCAGATGCTGAGTA
CCGTAAGCACCTTAATCAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10966.87 Da        Isoelectric Point: 9.7256

>AT45047 WP_014227313.1 NZ_CP004887:747031-747330 [Klebsiella michiganensis HKOPL1]
MATLKELMAKQSPESQARIAEKVEEMRQAIALSMLREELNMSQAELAKAMGVKQPTIAKMEQADNDPRLSTLKRYVAALG
GELSIDVKLPTGKRIAFHL

Download         Length: 300 bp

>AT45047 NZ_CP004887:747031-747330 [Klebsiella michiganensis HKOPL1]
ATGGCGACCCTTAAAGAATTAATGGCCAAACAGAGCCCGGAAAGCCAGGCGCGTATTGCTGAAAAAGTCGAGGAGATGCG
CCAGGCTATCGCTTTAAGTATGTTAAGGGAAGAACTCAATATGTCTCAGGCAGAGCTGGCTAAGGCAATGGGCGTTAAAC
AACCCACCATAGCAAAAATGGAACAGGCTGATAACGACCCGCGTTTGTCAACGCTGAAGCGCTATGTTGCAGCGCTCGGG
GGGGAACTCAGTATTGATGTTAAGCTGCCAACCGGTAAGCGAATCGCATTCCATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0H3H3K0

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3H3Q5

References