Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2563316..2563911 Replicon chromosome
Accession NZ_CP004381
Organism Burkholderia thailandensis E254

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag BTN_RS11840 Protein ID WP_043296409.1
Coordinates 2563633..2563911 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BTN_RS11835 Protein ID WP_043296407.1
Coordinates 2563316..2563615 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTN_RS11800 2559003..2559578 + 576 WP_043296397.1 hypothetical protein -
BTN_RS11805 2559578..2559892 + 315 WP_043296398.1 bacteriophage protein -
BTN_RS33205 2559955..2560719 + 765 WP_127462315.1 hypothetical protein -
BTN_RS11815 2560748..2561116 + 369 WP_102822916.1 hypothetical protein -
BTN_RS11820 2561158..2562126 + 969 WP_043296403.1 hypothetical protein -
BTN_RS11825 2562123..2562500 - 378 WP_043296405.1 hypothetical protein -
BTN_RS11830 2562504..2563253 + 750 WP_038782783.1 phage protein -
BTN_RS11835 2563316..2563615 - 300 WP_043296407.1 HigA family addiction module antidote protein Antitoxin
BTN_RS11840 2563633..2563911 - 279 WP_043296409.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BTN_RS11845 2563973..2564326 + 354 WP_038782788.1 hypothetical protein -
BTN_RS11850 2564323..2565504 + 1182 WP_043296410.1 bacteriophage protein -
BTN_RS11855 2565504..2566166 + 663 WP_043296412.1 DUF2612 domain-containing protein -
BTN_RS11860 2566216..2567436 - 1221 WP_011400919.1 ISL3-like element ISBma1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2512191..2573360 61169
- flank IS/Tn - - 2566216..2567436 1220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(25-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(8-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10743.21 Da        Isoelectric Point: 9.3525

>T45015 WP_043296409.1 NZ_CP004381:c2563911-2563633 [Burkholderia thailandensis E254]
MITSFNCRDTEALFNGTRVARFVNFERVSIRKLQQLHAAADLDFLRIPPNNRLEALKGDRQGQFSIRINDQWRICFKFAN
GRASDVEIVDYH

Download         Length: 279 bp

>T45015 NZ_CP004381:c2563911-2563633 [Burkholderia thailandensis E254]
ATGATTACATCGTTCAACTGCCGAGATACTGAGGCGCTGTTCAATGGCACGCGAGTCGCCCGCTTCGTCAATTTCGAACG
CGTCTCGATTCGCAAGCTCCAGCAGTTGCACGCTGCGGCCGATCTGGACTTCCTTCGCATCCCGCCGAACAACCGGCTCG
AAGCGCTGAAGGGCGACCGACAAGGCCAATTCAGCATCCGCATTAACGACCAGTGGCGTATCTGCTTCAAGTTCGCCAAT
GGACGCGCCTCGGATGTGGAAATCGTCGACTACCACTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11027.55 Da        Isoelectric Point: 4.8616

>AT45015 WP_043296407.1 NZ_CP004381:c2563615-2563316 [Burkholderia thailandensis E254]
MTREVPLATPGEILAEDWLEPMGISQYALAKAISVPARRINEIVKGDRAITADTAVRLGAFFGVDPQSWMNLQTHYDTEL
AKEKIGDDVLREIREHAHA

Download         Length: 300 bp

>AT45015 NZ_CP004381:c2563615-2563316 [Burkholderia thailandensis E254]
ATGACCCGAGAAGTACCCCTGGCGACGCCCGGTGAAATCCTGGCGGAAGACTGGCTGGAGCCGATGGGCATCAGCCAATA
CGCACTGGCGAAGGCGATCAGCGTCCCGGCTCGCCGCATTAACGAGATCGTGAAGGGCGACCGTGCCATCACGGCCGACA
CTGCAGTGCGCCTTGGTGCGTTCTTCGGCGTCGATCCGCAAAGCTGGATGAACCTCCAGACGCATTACGACACCGAACTC
GCCAAGGAAAAGATCGGCGACGATGTGCTACGCGAAATCCGCGAGCACGCGCACGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References