Detailed information of TA system TA044978

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2861707..2862044
• Replicon: chromosome
• Accession: NZ_CP004081
• Organism: Enterococcus faecalis DENG1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: E2Z0W4
• Locus tag: DENG_RS14380
• Protein ID: WP_002381035.1
• Coordinates: 2861707..2861850 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2861782..2862044 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DENG_RS14365	2857786..2858415	-	630	WP_002354763.1	lytic polysaccharide monooxygenase	-
DENG_RS14375	2859108..2860724	+	1617	WP_002381036.1	phosphatase PAP2/LCP family protein	-
DENG_RS15455	2861054..2861197	+	144	WP_002392818.1	putative holin-like toxin	-
DENG_RS15460	2861351..2861476	+	126	WP_080270854.1	putative holin-like toxin	-
DENG_RS14380	2861707..2861850	+	144	WP_002381035.1	putative holin-like toxin	Toxin
-	2861782..2862044	-	263	-	-	Antitoxin
DENG_RS14385	2862045..2866736	-	4692	WP_010783624.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5202.20 Da
• Isoelectric Point: 10.0041

>T44978 WP_002381035.1 NZ_CP004081:2861707-2861850 [Enterococcus faecalis DENG1]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Nucleotide

• Length: 144 bp

>T44978 NZ_CP004081:2861707-2861850 [Enterococcus faecalis DENG1]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTAAAAGAAAACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 263 bp

>AT44978 NZ_CP004081:c2862044-2861782 [Enterococcus faecalis DENG1]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGATGGTCGTTGTGCTACA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATATCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTTTTCTTTTACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: A0A2Z6BWH2

Antitoxin