Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2861409..2861850 Replicon chromosome
Accession NZ_CP004081
Organism Enterococcus faecalis DENG1

Toxin (Protein)


Gene name txpA Uniprot ID E2Z0W4
Locus tag DENG_RS14380 Protein ID WP_002381035.1
Coordinates 2861707..2861850 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2861409..2861607 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DENG_RS14360 2856530..2857522 + 993 WP_002354765.1 biotin--[acetyl-CoA-carboxylase] ligase -
DENG_RS14365 2857786..2858415 - 630 WP_002354763.1 lytic polysaccharide monooxygenase -
DENG_RS14375 2859108..2860724 + 1617 WP_002381036.1 phosphatase PAP2/LCP family protein -
DENG_RS15455 2861054..2861197 + 144 WP_002392818.1 putative holin-like toxin -
DENG_RS15460 2861351..2861476 + 126 WP_080270854.1 putative holin-like toxin -
- 2861409..2861607 - 199 - - Antitoxin
DENG_RS14380 2861707..2861850 + 144 WP_002381035.1 putative holin-like toxin Toxin
DENG_RS14385 2862045..2866736 - 4692 WP_010783624.1 WxL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5202.20 Da        Isoelectric Point: 10.0041

>T44975 WP_002381035.1 NZ_CP004081:2861707-2861850 [Enterococcus faecalis DENG1]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Download         Length: 144 bp

>T44975 NZ_CP004081:2861707-2861850 [Enterococcus faecalis DENG1]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTAAAAGAAAACAATAAAAAATAA

Antitoxin


Download         Length: 199 bp

>AT44975 NZ_CP004081:c2861607-2861409 [Enterococcus faecalis DENG1]
TTTTTAGGTAATTGTGCTATAATGGTAATGAAAAGAGAGCTATGCTGTAACATACCTCTCTGATGTAGAGCCGTTTAAGA
CGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATT
TCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z6BWH2

Antitoxin

Download structure file

References