Detailed information of TA system TA044966

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2861054..2861314
• Replicon: chromosome
• Accession: NZ_CP004081
• Organism: Enterococcus faecalis DENG1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: DENG_RS15455
• Protein ID: WP_002392818.1
• Coordinates: 2861054..2861197 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2861130..2861314 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DENG_RS14355	2856176..2856391	-	216	WP_002354768.1	zinc ribbon domain-containing protein	-
DENG_RS14360	2856530..2857522	+	993	WP_002354765.1	biotin--[acetyl-CoA-carboxylase] ligase	-
DENG_RS14365	2857786..2858415	-	630	WP_002354763.1	lytic polysaccharide monooxygenase	-
DENG_RS14375	2859108..2860724	+	1617	WP_002381036.1	phosphatase PAP2/LCP family protein	-
DENG_RS15455	2861054..2861197	+	144	WP_002392818.1	putative holin-like toxin	Toxin
-	2861130..2861314	-	185	-	-	Antitoxin
DENG_RS15460	2861351..2861476	+	126	WP_080270854.1	putative holin-like toxin	-
DENG_RS14380	2861707..2861850	+	144	WP_002381035.1	putative holin-like toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5344.49 Da
• Isoelectric Point: 10.6323

>T44966 WP_002392818.1 NZ_CP004081:2861054-2861197 [Enterococcus faecalis DENG1]
MNVSTKIYERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 144 bp

>T44966 NZ_CP004081:2861054-2861197 [Enterococcus faecalis DENG1]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACAATTCTTGGGTTTGG
TATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin

Nucleotide

• Length: 185 bp

>AT44966 NZ_CP004081:c2861314-2861130 [Enterococcus faecalis DENG1]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGCAATGGTAAACATACCAA

Structures

Antitoxin