Detailed information of TA system TA044962

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2782403..2782666
• Replicon: chromosome
• Accession: NZ_CP004081
• Organism: Enterococcus faecalis DENG1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: S4BYM2
• Locus tag: DENG_RS15425
• Protein ID: WP_002392696.1
• Coordinates: 2782523..2782666 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2782403..2782590 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DENG_RS14030	2777864..2780608	+	2745	WP_002406717.1	glycoside hydrolase family 65 protein	-
DENG_RS14035	2780623..2781273	+	651	WP_002354875.1	beta-phosphoglucomutase	-
DENG_RS14040	2781688..2782282	+	595	Protein_2670	hypothetical protein	-
-	2782403..2782590	+	188	-	-	Antitoxin
DENG_RS15425	2782523..2782666	-	144	WP_002392696.1	putative holin-like toxin	Toxin
DENG_RS15430	2783475..2783669	+	195	Protein_2672	CPBP family intramembrane metalloprotease	-
DENG_RS14045	2783722..2784693	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
DENG_RS14050	2784868..2785305	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
DENG_RS14055	2785438..2785992	-	555	WP_002354869.1	septum formation protein Maf	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5297.43 Da
• Isoelectric Point: 10.6867

>T44962 WP_002392696.1 NZ_CP004081:c2782666-2782523 [Enterococcus faecalis DENG1]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 144 bp

>T44962 NZ_CP004081:c2782666-2782523 [Enterococcus faecalis DENG1]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 188 bp

>AT44962 NZ_CP004081:2782403-2782590 [Enterococcus faecalis DENG1]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGCAGAACCGTTTAAGACGGTGACTTTTT
GAATTATTTAAAAATAACCGTACTCGGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGT
GCAATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: S4BYM2

Antitoxin