Detailed information of TA system TA044959

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2709417..2709669
• Replicon: chromosome
• Accession: NZ_CP004081
• Organism: Enterococcus faecalis DENG1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: DENG_RS13695
• Protein ID: WP_002393909.1
• Coordinates: 2709541..2709669 (-)
• Length: 43 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2709417..2709596 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DENG_RS13665	2704633..2705586	-	954	WP_002354964.1	siderophore ABC transporter substrate-binding protein	-
DENG_RS13670	2705625..2706380	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
DENG_RS13675	2706377..2707342	-	966	WP_002354961.1	iron chelate uptake ABC transporter family permease subunit	-
DENG_RS13680	2707339..2708286	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
DENG_RS13685	2708471..2708923	+	453	WP_002354958.1	YueI family protein	-
DENG_RS13690	2709108..2709235	-	128	Protein_2600	putative holin-like toxin	-
-	2709417..2709596	+	180	-	-	Antitoxin
DENG_RS13695	2709541..2709669	-	129	WP_002393909.1	hypothetical protein	Toxin
DENG_RS13700	2709832..2712102	-	2271	WP_002354955.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
DENG_RS13705	2712273..2712773	+	501	WP_002354954.1	cysteine hydrolase	-
DENG_RS13710	2713320..2714216	+	897	WP_002354953.1	YitT family protein	-
DENG_RS13715	2714267..2714665	-	399	WP_024797228.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (11-42)

Sequences

Toxin

Protein

• Length: 43 a.a.
• Molecular weight: 4743.64 Da
• Isoelectric Point: 5.6470

>T44959 WP_002393909.1 NZ_CP004081:c2709669-2709541 [Enterococcus faecalis DENG1]
MHFNERSIFLSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 129 bp

>T44959 NZ_CP004081:c2709669-2709541 [Enterococcus faecalis DENG1]
ATGCACTTTAACGAAAGGAGCATTTTTTTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGC
ACTACTGATTTTCGGTATCCTTGAAGCAACGAAAAACGATAAAAAATAA

Antitoxin

Nucleotide

• Length: 180 bp

>AT44959 NZ_CP004081:2709417-2709596 [Enterococcus faecalis DENG1]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAGTGCAACAA

Structures

Antitoxin