44936

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 416080..416698 Replicon chromosome
Accession NZ_CP004057
Organism Shigella flexneri Shi06HN006 isolate Human

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag SFYV_RS02195 Protein ID WP_001291435.1
Coordinates 416080..416298 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q0T7C3
Locus tag SFYV_RS02200 Protein ID WP_000344797.1
Coordinates 416324..416698 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SFYV_RS02170 (411972) 411972..412283 - 312 WP_000409911.1 MGMT family protein -
SFYV_RS02175 (412662) 412662..413015 + 354 WP_000878140.1 DUF1428 domain-containing protein -
SFYV_RS02180 (413057) 413057..414607 - 1551 WP_005098218.1 cyclic-guanylate-specific phosphodiesterase PdeB -
SFYV_RS02185 (414771) 414771..415241 - 471 WP_000136192.1 YlaC family protein -
SFYV_RS02190 (415357) 415357..415908 - 552 Protein_396 maltose O-acetyltransferase -
SFYV_RS02195 (416080) 416080..416298 - 219 WP_001291435.1 HHA domain-containing protein Toxin
SFYV_RS02200 (416324) 416324..416698 - 375 WP_000344797.1 Hha toxicity modulator TomB Antitoxin
SFYV_RS02205 (417244) 417244..420393 - 3150 WP_001132484.1 efflux RND transporter permease AcrB -
SFYV_RS02210 (420416) 420416..421609 - 1194 WP_011069267.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 410614..411942 1328


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T44936 WP_001291435.1 NZ_CP004057:c416298-416080 [Shigella flexneri Shi06HN006]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T44936 NZ_CP004057:c416298-416080 [Shigella flexneri Shi06HN006]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14513.38 Da        Isoelectric Point: 4.9091

>AT44936 WP_000344797.1 NZ_CP004057:c416698-416324 [Shigella flexneri Shi06HN006]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQALQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT44936 NZ_CP004057:c416698-416324 [Shigella flexneri Shi06HN006]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGTTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGCTCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAACGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TPD8

References