Detailed information of TA system TA044928

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2081980..2082205
• Replicon: chromosome
• Accession: NZ_CP004056
• Organism: Shigella flexneri 2003036 isolate Human

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: SFY_RS11625
• Protein ID: WP_000935258.1
• Coordinates: 2081980..2082192 (-)
• Length: 71 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2082147..2082205 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SFY_RS11570	2077292..2077642	-	351	WP_005048975.1	IS66 family insertion sequence element accessory protein TnpB	-
SFY_RS11575	2077639..2078313	-	675	WP_001088287.1	IS66 family insertion sequence hypothetical protein	-
SFY_RS11580	2078412..2078627	-	216	WP_000839572.1	class II holin family protein	-
SFY_RS11605	2079428..2080111	-	684	WP_005049343.1	antiterminator	-
SFY_RS11610	2080108..2080473	-	366	WP_000140020.1	RusA family crossover junction endodeoxyribonuclease	-
SFY_RS11615	2080474..2081532	-	1059	WP_001265248.1	DUF968 domain-containing protein	-
SFY_RS26155	2081534..2081812	-	279	WP_011069426.1	hypothetical protein	-
SFY_RS11625	2081980..2082192	-	213	WP_000935258.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	2082147..2082205	+	59	-	-	Antitoxin
SFY_RS11635	2082787..2083203	-	417	WP_005069274.1	hypothetical protein	-
SFY_RS11640	2083230..2083370	+	141	Protein_2105	DUF4224 domain-containing protein	-
SFY_RS11645	2083370..2084395	+	1026	WP_000533619.1	tyrosine-type recombinase/integrase	-
SFY_RS11655	2084631..2085428	+	798	WP_001325918.1	DgsA anti-repressor MtfA	-
SFY_RS11665	2085766..2087028	+	1263	Protein_2108	tyrosine-type recombinase/integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	ipaH7.8	2050128..2109089	58961

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 71 a.a.
• Molecular weight: 7856.42 Da
• Isoelectric Point: 8.7469

>T44928 WP_000935258.1 NZ_CP004056:c2082192-2081980 [Shigella flexneri 2003036]
MLNTCRLASYVPKGKEKQAMKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 213 bp

>T44928 NZ_CP004056:c2082192-2081980 [Shigella flexneri 2003036]
ATGCTGAACACATGTAGGTTAGCCTCTTACGTGCCGAAAGGCAAGGAGAAGCAGGCTATGAAGCAGCAAAAGGCGATGTT
AATCGCCCTTATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAAAGACCTCTGCGAGGTACGAATCC
GAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT44928 NZ_CP004056:2082147-2082205 [Shigella flexneri 2003036]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Structures

Antitoxin