Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 1420012..1420237 Replicon chromosome
Accession NZ_CP004056
Organism Shigella flexneri 2003036 isolate Human

Toxin (Protein)


Gene name hokW Uniprot ID -
Locus tag SFY_RS07730 Protein ID WP_000018421.1
Coordinates 1420025..1420237 (+) Length 71 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 1420012..1420070 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SFY_RS29250 1415578..1415832 + 255 Protein_1387 hypothetical protein -
SFY_RS07690 1416325..1417071 + 747 WP_000788996.1 ATP-binding protein -
SFY_RS07695 1417086..1417508 + 423 WP_001118168.1 DUF977 family protein -
SFY_RS07700 1417566..1417922 + 357 WP_005048249.1 hypothetical protein -
SFY_RS07705 1418015..1418233 + 219 WP_000256998.1 DUF4014 family protein -
SFY_RS07710 1418235..1418600 + 366 WP_001229297.1 HNH endonuclease -
SFY_RS07715 1418597..1419262 + 666 WP_000208062.1 hypothetical protein -
SFY_RS07720 1419262..1419627 + 366 WP_000610655.1 DUF551 domain-containing protein -
- 1420012..1420070 - 59 - - Antitoxin
SFY_RS07730 1420025..1420237 + 213 WP_000018421.1 type I toxin-antitoxin system Hok family toxin Toxin
SFY_RS07740 1420743..1421440 - 698 Protein_1396 IS1 family transposase -
SFY_RS07750 1421574..1422173 + 600 WP_000940329.1 DUF1367 family protein -
SFY_RS07755 1422173..1422463 + 291 WP_000228038.1 DUF1364 domain-containing protein -
SFY_RS07760 1422460..1423014 + 555 WP_000640143.1 DUF1133 family protein -
SFY_RS27760 1423155..1423340 + 186 WP_005049799.1 hypothetical protein -
SFY_RS07775 1423402..1424558 + 1157 WP_094081518.1 IS3 family transposase -
SFY_RS07780 1424586..1424954 + 369 WP_011069357.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage sitABCD ipaH9.8 / ipaH9.8 1412095..1466976 54881


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(25-66)


Sequences


Toxin        


Download         Length: 71 a.a.        Molecular weight: 7880.44 Da        Isoelectric Point: 9.2663

>T44917 WP_000018421.1 NZ_CP004056:1420025-1420237 [Shigella flexneri 2003036]
MSHKCRLASYVPKGKEKQAMKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Download         Length: 213 bp

>T44917 NZ_CP004056:1420025-1420237 [Shigella flexneri 2003036]
ATGTCTCACAAATGTAGGTTAGCCTCTTACGTGCCGAAAGGCAAGGAGAAGCAGGCTATGAAGCAGCAAAAGGCGATGTT
AATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAAAGACCTCTGCGAGGTACGAATCC
GAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 59 bp

>AT44917 NZ_CP004056:c1420070-1420012 [Shigella flexneri 2003036]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATTTGTGAGACATAGATTGGGCCTCA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Download structure file

References