Detailed information of TA system TA044856

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4418464..4419092
• Replicon: chromosome
• Accession: NZ_CP003424
• Organism: Serratia sp. SCBI

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A8B4GSN3
• Locus tag: SERRSCBI_RS20590
• Protein ID: WP_042785415.1
• Coordinates: 4418464..4418754 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: SERRSCBI_RS20595
• Protein ID: WP_042785416.1
• Coordinates: 4418769..4419092 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SERRSCBI_RS20580	4414878..4416899	+	2022	WP_042785413.1	NADPH-dependent 2,4-dienoyl-CoA reductase	-
SERRSCBI_RS20585	4417094..4418233	-	1140	WP_042785414.1	23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG	-
SERRSCBI_RS20590	4418464..4418754	+	291	WP_042785415.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SERRSCBI_RS20595	4418769..4419092	+	324	WP_042785416.1	HigA family addiction module antidote protein	Antitoxin
SERRSCBI_RS20600	4419085..4419597	+	513	WP_042785417.1	M48 family metallopeptidase	-
SERRSCBI_RS20605	4419648..4420628	+	981	WP_042785418.1	Gfo/Idh/MocA family oxidoreductase	-
SERRSCBI_RS20610	4420630..4421361	+	732	WP_042785419.1	glutamine amidotransferase	-
SERRSCBI_RS20615	4421617..4422582	+	966	WP_198036342.1	TerC family protein	-
SERRSCBI_RS20620	4422846..4424081	+	1236	WP_028128305.1	serine/threonine transporter SstT	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (1-94)

Antitoxin

• Cro/C1-type helix-turn-helix domain (24-71)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11672.37 Da
• Isoelectric Point: 10.4297

>T44856 WP_042785415.1 NZ_CP003424:4418464-4418754 [Serratia sp. SCBI]
MIKSFRDRYLEQFYLEGRRSRLIPGALERQLARKLDMLAAAQQERDLHHPKGNYYKRLSGPFQGWSSLRVNMHWRLMFQW
RHDAAEKIYLDPHQDT

Nucleotide

• Length: 291 bp

>T44856 NZ_CP003424:4418464-4418754 [Serratia sp. SCBI]
ATGATTAAATCTTTCCGCGATCGCTATCTGGAGCAGTTCTATCTGGAAGGCAGGCGCAGCCGTCTTATCCCCGGCGCGCT
CGAGCGGCAGTTGGCCAGAAAGCTCGATATGTTAGCCGCCGCGCAGCAAGAGCGTGATTTGCATCACCCCAAGGGTAACT
ATTACAAGCGGCTATCCGGGCCATTTCAGGGATGGTCGAGTCTGCGCGTCAATATGCACTGGCGGCTGATGTTCCAGTGG
CGGCATGATGCCGCCGAAAAAATTTACCTCGATCCTCACCAAGATACCTGA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12127.76 Da
• Isoelectric Point: 6.2285

>AT44856 WP_042785416.1 NZ_CP003424:4418769-4419092 [Serratia sp. SCBI]
MLETTSREPTTVGEVLQEEYLTPLGIGQEELAKVLGVTRATVNRLCNGHRRMSVAEANLFADLFETTADFWLNLQAAHDR
WEARQADAQRVRLRPIKEILGRNITHA

Nucleotide

• Length: 324 bp

>AT44856 NZ_CP003424:4418769-4419092 [Serratia sp. SCBI]
ATGTTGGAAACCACGTCTCGCGAACCCACCACGGTGGGAGAAGTGCTGCAGGAAGAATATTTAACGCCGTTAGGCATCGG
CCAAGAAGAACTGGCAAAGGTATTGGGCGTCACCCGCGCCACCGTCAATCGCCTGTGCAACGGGCATCGACGCATGAGCG
TTGCCGAGGCCAATCTGTTTGCCGATCTGTTCGAAACGACCGCCGACTTTTGGCTAAACCTGCAGGCGGCACACGATCGC
TGGGAAGCCAGACAGGCCGATGCGCAGCGTGTGCGGCTGCGGCCAATTAAAGAAATACTGGGACGCAATATCACTCATGC
ATGA

Structures

Toxin

• AlphaFold DB: A0A8B4GSN3