Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3361404..3362064 Replicon chromosome
Accession NZ_CP003424
Organism Serratia sp. SCBI

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag SERRSCBI_RS15775 Protein ID WP_042785020.1
Coordinates 3361711..3362064 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8G2G5Z5
Locus tag SERRSCBI_RS15770 Protein ID WP_016927038.1
Coordinates 3361404..3361706 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SERRSCBI_RS15750 3357008..3357922 - 915 WP_033643752.1 branched-chain amino acid ABC transporter permease -
SERRSCBI_RS15755 3358047..3359165 - 1119 WP_042785018.1 branched-chain amino acid ABC transporter substrate-binding protein -
SERRSCBI_RS15765 3359771..3360978 - 1208 Protein_3150 aldose 1-epimerase family protein -
SERRSCBI_RS15770 3361404..3361706 - 303 WP_016927038.1 XRE family transcriptional regulator Antitoxin
SERRSCBI_RS15775 3361711..3362064 - 354 WP_042785020.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SERRSCBI_RS15780 3362503..3363798 + 1296 WP_033643756.1 MFS transporter -
SERRSCBI_RS15785 3363825..3364631 + 807 WP_033651878.1 substrate-binding domain-containing protein -
SERRSCBI_RS15790 3364606..3365505 - 900 WP_033651879.1 LysR family transcriptional regulator -
SERRSCBI_RS15795 3365608..3365973 - 366 WP_033643759.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13493.38 Da        Isoelectric Point: 8.4803

>T44854 WP_042785020.1 NZ_CP003424:c3362064-3361711 [Serratia sp. SCBI]
VWEIKTTDAFDHWFRSLSDADRAGVLAALMVLREKGPGLPSPYADTVKGSRYSNMKELRIQCRGEPLRAFFAFDPYRIGI
VLCAGNKASNEKRFYDRMIQVADREFTNWLNTLNEKE

Download         Length: 354 bp

>T44854 NZ_CP003424:c3362064-3361711 [Serratia sp. SCBI]
GTGTGGGAAATTAAAACAACGGATGCATTTGATCATTGGTTCAGATCGCTCAGCGATGCCGATCGGGCCGGCGTACTTGC
TGCATTGATGGTCCTGCGGGAAAAGGGGCCGGGGCTGCCCAGCCCCTATGCCGATACGGTTAAAGGCTCACGTTACAGCA
ATATGAAAGAGTTGCGCATTCAGTGCCGAGGCGAACCGTTGCGGGCATTCTTCGCTTTCGATCCGTACCGTATTGGCATT
GTGCTTTGCGCGGGCAATAAAGCCAGTAATGAAAAGCGTTTTTACGATCGGATGATCCAGGTTGCCGATCGGGAATTCAC
GAACTGGCTGAACACATTAAACGAGAAGGAGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11093.96 Da        Isoelectric Point: 6.4738

>AT44854 WP_016927038.1 NZ_CP003424:c3361706-3361404 [Serratia sp. SCBI]
MGRTLEQLIADEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDIELPDGSHYEFVL

Download         Length: 303 bp

>AT44854 NZ_CP003424:c3361706-3361404 [Serratia sp. SCBI]
ATGGGCAGAACGTTGGAACAGCTTATTGCGGATGAAAAGCCCGAGGTCGTGGCCAAAGCGCAGGCGCTGGCGGCGGACAT
CATGCTGAACATTCACCTTGCCGAGCTGCGTGAAAAAGTACAGAAAACGCAGGTTGAAATGGCGCAGGCGCTGGGGATCA
GGCAGCCGACCGTTGCCGTGATGGAAAAACCGGGCCGCGATCTGAAACTGTCTTCGCTTAAACGCTATGTTGAGGCGGCC
GGCGGCAAACTGCGCCTGGACATTGAACTGCCGGACGGCTCTCACTACGAGTTTGTGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References