Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1358954..1359535 Replicon chromosome
Accession NZ_CP003182
Organism Granulibacter bethesdensis CGDNIH4

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag GBCGDNIH4_RS06250 Protein ID WP_025320630.1
Coordinates 1358954..1359232 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GBCGDNIH4_RS06255 Protein ID WP_025320629.1
Coordinates 1359245..1359535 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GBCGDNIH4_RS06245 1358193..1358897 - 705 WP_025320631.1 hypothetical protein -
GBCGDNIH4_RS06250 1358954..1359232 + 279 WP_025320630.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GBCGDNIH4_RS06255 1359245..1359535 + 291 WP_025320629.1 HigA family addiction module antidote protein Antitoxin
GBCGDNIH4_RS06260 1359537..1359785 - 249 WP_155760869.1 hypothetical protein -
GBCGDNIH4_RS06265 1359878..1360342 - 465 WP_025320627.1 hypothetical protein -
GBCGDNIH4_RS06270 1360372..1361616 - 1245 WP_025320626.1 hypothetical protein -
GBCGDNIH4_RS06275 1361650..1362051 - 402 WP_025320625.1 hypothetical protein -
GBCGDNIH4_RS06280 1362051..1362374 - 324 WP_025320624.1 hypothetical protein -
GBCGDNIH4_RS06285 1362386..1362700 - 315 WP_025319155.1 hypothetical protein -
GBCGDNIH4_RS06290 1362697..1363296 - 600 WP_025320623.1 hypothetical protein -
GBCGDNIH4_RS06295 1363299..1363514 - 216 WP_155760870.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1342274..1389056 46782


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(2-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10627.01 Da        Isoelectric Point: 6.9803

>T44837 WP_025320630.1 NZ_CP003182:1358954-1359232 [Granulibacter bethesdensis CGDNIH4]
MIKSWADKAAQELFETGRSRRWATIRKVIQRKLDMLDAATALDDLRSPPGNRLEMLSGDRAGQYSIRVNDQFRICFNWTE
AGPENVEVVDYH

Download         Length: 279 bp

>T44837 NZ_CP003182:1358954-1359232 [Granulibacter bethesdensis CGDNIH4]
ATGATCAAGTCATGGGCAGACAAGGCGGCGCAGGAGCTTTTCGAGACGGGTCGCTCAAGGCGATGGGCAACGATCAGGAA
AGTTATCCAGCGCAAGCTGGATATGCTTGATGCCGCCACCGCGCTGGATGATCTGCGATCCCCGCCAGGCAACCGGCTGG
AAATGCTGAGTGGTGACCGGGCGGGGCAATACAGCATCCGCGTGAACGATCAGTTTCGCATCTGTTTCAACTGGACCGAG
GCCGGACCGGAAAATGTTGAAGTTGTCGATTACCACTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10685.32 Da        Isoelectric Point: 7.4029

>AT44837 WP_025320629.1 NZ_CP003182:1359245-1359535 [Granulibacter bethesdensis CGDNIH4]
MTRIRTHPGEILQEEFLVPLGLTANALARALHVPANRITAIIADQRGITADTALRLARYFRTTPQFWLNLQAGYDLSLIE
AERGHDIAMTITPHAP

Download         Length: 291 bp

>AT44837 NZ_CP003182:1359245-1359535 [Granulibacter bethesdensis CGDNIH4]
ATGACCCGTATCAGAACCCATCCGGGAGAAATCCTGCAGGAAGAATTTCTGGTCCCTTTGGGCCTGACCGCAAACGCTCT
GGCGCGTGCCCTGCACGTTCCGGCCAACCGCATCACCGCCATCATTGCCGACCAGCGCGGCATCACGGCGGATACGGCGC
TCCGGCTGGCCCGGTATTTCCGCACGACACCGCAATTCTGGCTGAACCTTCAGGCTGGTTACGATCTTTCTCTGATCGAG
GCAGAGCGCGGGCATGATATCGCAATGACGATCACGCCACACGCGCCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References