Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2968007..2968655 Replicon chromosome
Accession NZ_CP002885
Organism Mycobacterium tuberculosis CCDC5180

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag CFBR_RS14005 Protein ID WP_003899414.1
Coordinates 2968007..2968330 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag CFBR_RS14010 Protein ID WP_003899415.1
Coordinates 2968410..2968655 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFBR_RS13975 2963330..2964328 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
CFBR_RS13980 2964342..2964806 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
CFBR_RS13985 2964794..2965045 + 252 WP_003908028.1 hypothetical protein -
CFBR_RS13990 2965216..2966655 - 1440 WP_003901443.1 phage major capsid protein -
CFBR_RS13995 2966663..2967196 - 534 WP_003899412.1 HK97 family phage prohead protease -
CFBR_RS21660 2967349..2967840 - 492 WP_003900541.1 phage terminase small subunit P27 family -
CFBR_RS14005 2968007..2968330 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
CFBR_RS14010 2968410..2968655 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
CFBR_RS14015 2968652..2970079 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
CFBR_RS14020 2970081..2970473 - 393 WP_003899417.1 DUF2742 domain-containing protein -
CFBR_RS14025 2970470..2970730 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
CFBR_RS14030 2970747..2971109 - 363 WP_003900543.1 hypothetical protein -
CFBR_RS14035 2971112..2972239 - 1128 WP_003899420.1 site-specific integrase -
CFBR_RS14040 2972384..2972611 - 228 WP_003899421.1 hypothetical protein -
CFBR_RS21665 2972608..2972997 - 390 WP_003899422.1 hypothetical protein -
CFBR_RS14045 2972903..2973175 + 273 WP_003900544.1 hypothetical protein -
CFBR_RS14050 2973274..2973507 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2963330..2972239 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(10-103)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T44822 WP_003899414.1 NZ_CP002885:c2968330-2968007 [Mycobacterium tuberculosis CCDC5180]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T44822 NZ_CP002885:c2968330-2968007 [Mycobacterium tuberculosis CCDC5180]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT44822 WP_003899415.1 NZ_CP002885:c2968655-2968410 [Mycobacterium tuberculosis CCDC5180]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT44822 NZ_CP002885:c2968655-2968410 [Mycobacterium tuberculosis CCDC5180]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References