Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2964822..2965470 Replicon chromosome
Accession NZ_CP002883
Organism Mycobacterium tuberculosis BT1

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag HKBT1_RS13990 Protein ID WP_003899414.1
Coordinates 2964822..2965145 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag HKBT1_RS13995 Protein ID WP_003899415.1
Coordinates 2965225..2965470 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKBT1_RS13960 2960145..2961143 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
HKBT1_RS13965 2961157..2961621 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
HKBT1_RS13970 2961609..2961860 + 252 WP_003908028.1 hypothetical protein -
HKBT1_RS13975 2962031..2963470 - 1440 WP_003901443.1 phage major capsid protein -
HKBT1_RS13980 2963478..2964011 - 534 WP_003899412.1 HK97 family phage prohead protease -
HKBT1_RS21650 2964164..2964655 - 492 WP_003900541.1 phage terminase small subunit P27 family -
HKBT1_RS13990 2964822..2965145 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
HKBT1_RS13995 2965225..2965470 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
HKBT1_RS14000 2965467..2966894 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
HKBT1_RS14005 2966896..2967288 - 393 WP_003899417.1 DUF2742 domain-containing protein -
HKBT1_RS14010 2967285..2967545 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
HKBT1_RS14015 2967562..2967924 - 363 WP_003900543.1 hypothetical protein -
HKBT1_RS14020 2967927..2969054 - 1128 WP_003899420.1 site-specific integrase -
HKBT1_RS14025 2969199..2969426 - 228 WP_003899421.1 hypothetical protein -
HKBT1_RS21655 2969423..2969812 - 390 WP_003899422.1 hypothetical protein -
HKBT1_RS14030 2969718..2969990 + 273 WP_003900544.1 hypothetical protein -
HKBT1_RS14035 2970089..2970322 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2960145..2969054 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T44762 WP_003899414.1 NZ_CP002883:c2965145-2964822 [Mycobacterium tuberculosis BT1]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T44762 NZ_CP002883:c2965145-2964822 [Mycobacterium tuberculosis BT1]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT44762 WP_003899415.1 NZ_CP002883:c2965470-2965225 [Mycobacterium tuberculosis BT1]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT44762 NZ_CP002883:c2965470-2965225 [Mycobacterium tuberculosis BT1]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References