Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2258535..2259454 Replicon chromosome
Accession NZ_CP002883
Organism Mycobacterium tuberculosis BT1

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag HKBT1_RS21395 Protein ID WP_024753682.1
Coordinates 2258849..2259454 (-) Length 202 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID L7N5K9
Locus tag HKBT1_RS10605 Protein ID WP_003410124.1
Coordinates 2258535..2258840 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKBT1_RS10565 2253798..2253998 + 201 Protein_2073 hypothetical protein -
HKBT1_RS10580 2255354..2255731 + 378 Protein_2075 hypothetical protein -
HKBT1_RS10585 2255728..2256768 + 1041 WP_003410103.1 ImmA/IrrE family metallo-endopeptidase -
HKBT1_RS10590 2257010..2257729 + 720 WP_003410108.1 DUF433 domain-containing protein -
HKBT1_RS10595 2257719..2258135 + 417 WP_003410114.1 hypothetical protein -
HKBT1_RS10600 2258151..2258450 - 300 WP_003410120.1 hypothetical protein -
HKBT1_RS10605 2258535..2258840 - 306 WP_003410124.1 XRE family transcriptional regulator Antitoxin
HKBT1_RS21395 2258849..2259454 - 606 WP_024753682.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HKBT1_RS10615 2259479..2259838 - 360 WP_003410131.1 hypothetical protein -
HKBT1_RS10620 2259998..2260675 - 678 WP_003905725.1 hypothetical protein -
HKBT1_RS10625 2260627..2260863 - 237 WP_003410133.1 hypothetical protein -
HKBT1_RS10630 2261070..2261966 - 897 WP_003410136.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(86-181)

Antitoxin

HigA2-like, helix-turn-helix domain

(32-92)


Sequences

Toxin        


Download         Length: 202 a.a.        Molecular weight: 22743.97 Da        Isoelectric Point: 7.6272

>T44752 WP_024753682.1 NZ_CP002883:c2259454-2258849 [Mycobacterium tuberculosis BT1]
VNVPWENAHGGALYCLIRGNEFSAWHRLLFQRPGCAESVLACRHFLDGSPVARCSYPEEYHPCVISRIALLCDSVGWTAD
VERISAWLNGLDRETYELVFAAIEVLEEEGPALGCPLVDTVRGSRHKNMKELRPGSQGRSEVRILFAFDPARQAIMLAAG
NKAGRWTQWYDEKIKAADEMFAEHLAQFEDTKPKRRKRKKG

Download         Length: 606 bp

>T44752 NZ_CP002883:c2259454-2258849 [Mycobacterium tuberculosis BT1]
GTGAACGTTCCATGGGAGAACGCGCACGGCGGCGCACTGTACTGCCTCATACGTGGGAATGAATTCTCGGCCTGGCACAG
GCTACTGTTTCAACGGCCCGGGTGCGCAGAGTCCGTCCTCGCCTGCCGGCATTTCCTCGACGGTAGCCCCGTCGCCCGCT
GCTCTTACCCGGAGGAATATCACCCTTGTGTGATATCGCGTATCGCGCTACTCTGCGACTCTGTGGGGTGGACGGCGGAT
GTGGAGCGCATCTCCGCCTGGCTCAACGGCTTGGACCGAGAGACCTACGAATTGGTGTTCGCAGCTATCGAGGTTCTCGA
GGAAGAGGGCCCCGCACTTGGCTGTCCTCTGGTGGACACGGTGCGTGGGTCGCGCCACAAGAACATGAAGGAGCTGCGTC
CAGGATCACAAGGGCGGTCCGAGGTCCGCATTCTGTTCGCCTTCGACCCGGCGCGGCAGGCGATCATGCTGGCCGCCGGT
AACAAGGCCGGGCGGTGGACCCAGTGGTACGACGAGAAGATCAAAGCGGCCGATGAGATGTTTGCCGAACATCTCGCACA
GTTCGAGGACACGAAGCCAAAGAGGCGCAAGCGCAAGAAAGGGTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11291.91 Da        Isoelectric Point: 10.7482

>AT44752 WP_003410124.1 NZ_CP002883:c2258840-2258535 [Mycobacterium tuberculosis BT1]
MAMTLRDMDAVRPVNREAVDRHKARMRDEVRAFRLRELRAAQSLTQVQVAALAHIRQSRVSSIENGDIGSAQVNTLRKYV
SALGGELDITVRLGDETFTLA

Download         Length: 306 bp

>AT44752 NZ_CP002883:c2258840-2258535 [Mycobacterium tuberculosis BT1]
ATGGCGATGACACTACGGGACATGGACGCCGTACGTCCCGTTAACCGGGAGGCGGTGGACCGGCACAAGGCACGAATGCG
CGATGAAGTGCGGGCGTTCCGGCTCCGGGAGCTGCGCGCGGCTCAGTCACTCACCCAGGTCCAGGTGGCTGCGCTGGCGC
ACATCCGGCAGAGCCGGGTATCCAGCATCGAGAACGGCGACATCGGCTCCGCACAGGTCAACACACTGCGCAAATACGTG
TCCGCTCTTGGCGGAGAACTGGATATCACCGTCCGCCTGGGAGATGAGACATTCACCCTGGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 7EWC
PDB 7EWD
PDB 7EWE
AlphaFold DB A0A7U4BV30

References