Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2957425..2958073 Replicon chromosome
Accession NZ_CP002882
Organism Mycobacterium tuberculosis BT2

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag HKBT2_RS13965 Protein ID WP_003899414.1
Coordinates 2957425..2957748 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag HKBT2_RS13970 Protein ID WP_003899415.1
Coordinates 2957828..2958073 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKBT2_RS13935 2952748..2953746 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
HKBT2_RS13940 2953760..2954224 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
HKBT2_RS13945 2954212..2954463 + 252 WP_003908028.1 hypothetical protein -
HKBT2_RS13950 2954634..2956073 - 1440 WP_003901443.1 phage major capsid protein -
HKBT2_RS13955 2956081..2956614 - 534 WP_003899412.1 HK97 family phage prohead protease -
HKBT2_RS21590 2956767..2957258 - 492 WP_003900541.1 phage terminase small subunit P27 family -
HKBT2_RS13965 2957425..2957748 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
HKBT2_RS13970 2957828..2958073 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
HKBT2_RS13975 2958070..2959497 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
HKBT2_RS13980 2959499..2959891 - 393 WP_003899417.1 DUF2742 domain-containing protein -
HKBT2_RS13985 2959888..2960148 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
HKBT2_RS13990 2960165..2960527 - 363 WP_003900543.1 hypothetical protein -
HKBT2_RS13995 2960530..2961657 - 1128 WP_003899420.1 site-specific integrase -
HKBT2_RS14000 2961802..2962029 - 228 WP_003899421.1 hypothetical protein -
HKBT2_RS21595 2962026..2962415 - 390 WP_003899422.1 hypothetical protein -
HKBT2_RS14005 2962321..2962593 + 273 WP_003900544.1 hypothetical protein -
HKBT2_RS14010 2962692..2962925 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2952748..2961657 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Antitoxin MqsA/HigA-2

(2-132)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T44702 WP_003899414.1 NZ_CP002882:c2957748-2957425 [Mycobacterium tuberculosis BT2]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T44702 NZ_CP002882:c2957748-2957425 [Mycobacterium tuberculosis BT2]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT44702 WP_003899415.1 NZ_CP002882:c2958073-2957828 [Mycobacterium tuberculosis BT2]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT44702 NZ_CP002882:c2958073-2957828 [Mycobacterium tuberculosis BT2]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References