44642

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2967195..2967843 Replicon chromosome
Accession NZ_CP002871
Organism Mycobacterium tuberculosis HKBS1

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag HKBS1_RS13995 Protein ID WP_003899414.1
Coordinates 2967195..2967518 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag HKBS1_RS14000 Protein ID WP_003899415.1
Coordinates 2967598..2967843 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKBS1_RS13965 2962518..2963516 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
HKBS1_RS13970 2963530..2963994 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
HKBS1_RS13975 2963982..2964233 + 252 WP_003908028.1 hypothetical protein -
HKBS1_RS13980 2964404..2965843 - 1440 WP_003901443.1 phage major capsid protein -
HKBS1_RS13985 2965851..2966384 - 534 WP_003899412.1 HK97 family phage prohead protease -
HKBS1_RS21590 2966537..2967028 - 492 WP_003900541.1 phage terminase small subunit P27 family -
HKBS1_RS13995 2967195..2967518 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
HKBS1_RS14000 2967598..2967843 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
HKBS1_RS14005 2967840..2969267 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
HKBS1_RS14010 2969269..2969661 - 393 WP_003899417.1 DUF2742 domain-containing protein -
HKBS1_RS14015 2969658..2969918 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
HKBS1_RS14020 2969935..2970297 - 363 WP_003900543.1 hypothetical protein -
HKBS1_RS14025 2970300..2971427 - 1128 WP_003899420.1 site-specific integrase -
HKBS1_RS14030 2971572..2971799 - 228 WP_003899421.1 hypothetical protein -
HKBS1_RS21595 2971796..2972185 - 390 WP_003899422.1 hypothetical protein -
HKBS1_RS14035 2972091..2972363 + 273 WP_003900544.1 hypothetical protein -
HKBS1_RS14040 2972462..2972695 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2962518..2971427 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(11-89)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T44642 WP_003899414.1 NZ_CP002871:c2967518-2967195 [Mycobacterium tuberculosis HKBS1]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T44642 NZ_CP002871:c2967518-2967195 [Mycobacterium tuberculosis HKBS1]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT44642 WP_003899415.1 NZ_CP002871:c2967843-2967598 [Mycobacterium tuberculosis HKBS1]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT44642 NZ_CP002871:c2967843-2967598 [Mycobacterium tuberculosis HKBS1]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References