44592

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2009468..2009987 Replicon chromosome
Accession NZ_CP002007
Organism Streptococcus suis 05HAS68

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0K2E7Z7
Locus tag HAS68_RS10030 Protein ID WP_013730620.1
Coordinates 2009468..2009725 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag HAS68_RS10035 Protein ID WP_002939010.1
Coordinates 2009727..2009987 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAS68_RS10015 2005939..2007669 - 1731 WP_009910905.1 membrane protein -
HAS68_RS10020 2008032..2008940 - 909 WP_074411269.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
HAS68_RS10025 2008924..2009454 - 531 WP_009910909.1 DUF1697 domain-containing protein -
HAS68_RS10030 2009468..2009725 - 258 WP_013730620.1 Txe/YoeB family addiction module toxin Toxin
HAS68_RS10035 2009727..2009987 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HAS68_RS10040 2010063..2010518 - 456 WP_013730621.1 8-oxo-dGTP diphosphatase -
HAS68_RS10045 2010522..2010890 - 369 WP_009910914.1 hypothetical protein -
HAS68_RS10050 2010883..2011452 - 570 WP_022540720.1 ribonuclease M5 -
HAS68_RS10055 2011436..2012218 - 783 WP_002939015.1 TatD family hydrolase -
HAS68_RS10060 2012326..2012463 - 138 WP_002939016.1 50S ribosomal protein L34 -
HAS68_RS10065 2012631..2013626 - 996 WP_013730624.1 protein jag -
HAS68_RS10070 2013646..2014458 - 813 WP_004194552.1 YidC/Oxa1 family membrane protein insertase -
HAS68_RS10075 2014442..2014801 - 360 WP_013730625.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.86 Da        Isoelectric Point: 8.0279

>T44592 WP_013730620.1 NZ_CP002007:c2009725-2009468 [Streptococcus suis 05HAS68]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

>T44592 NZ_CP002007:c2009725-2009468 [Streptococcus suis 05HAS68]
ATGGGAATCCATTTTACAGACGACGCCTGGGAAGACTATCTTTATTGGCAGGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAGATTATCAAGGATATGCAGCGACATCCTTTTGAAGGCATTGCCAAACCAGAACCTTTGAAGTATGATTATCAAG
GTGCCTGGTCTCGGAGAATTGATGCGGAGAATCGGTTGATTTATATGGTGGAAGCTGATCGGTTGTGCATCCTGTCGCTA
AAGGATCATTATAGGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT44592 WP_002939010.1 NZ_CP002007:c2009987-2009727 [Streptococcus suis 05HAS68]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp

>AT44592 NZ_CP002007:c2009987-2009727 [Streptococcus suis 05HAS68]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAATGACGAGTTTGAACCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTCCTACGTGGTATGGCTAAAGTCAAAACGGGACAAACCCAAGAACGA
AACCTGATAGAGGCGGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E7Z7

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References