Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 362197..362825 Replicon chromosome
Accession NZ_AP028139
Organism Polynucleobacter sp. HIN8

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag QUE65_RS01915 Protein ID WP_286281517.1
Coordinates 362502..362825 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QUE65_RS01910 Protein ID WP_286281515.1
Coordinates 362197..362505 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE65_RS01890 (PHIN8_03610) 357949..359871 + 1923 WP_286281510.1 1-deoxy-D-xylulose-5-phosphate synthase -
QUE65_RS01895 (PHIN8_03620) 359929..360753 + 825 WP_286281512.1 GTP cyclohydrolase FolE2 -
QUE65_RS01900 (PHIN8_03630) 360740..361813 - 1074 WP_286281514.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD -
QUE65_RS01905 (PHIN8_03640) 361900..362112 + 213 WP_011903537.1 30S ribosomal protein S21 -
QUE65_RS01910 (PHIN8_03650) 362197..362505 - 309 WP_286281515.1 helix-turn-helix transcriptional regulator Antitoxin
QUE65_RS01915 (PHIN8_03660) 362502..362825 - 324 WP_286281517.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QUE65_RS01920 (PHIN8_03670) 363025..363471 + 447 WP_286281518.1 GatB/YqeY domain-containing protein -
QUE65_RS01925 (PHIN8_03680) 363483..365375 + 1893 WP_286281520.1 DNA primase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-98)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12401.71 Da        Isoelectric Point: 10.2188

>T44571 WP_286281517.1 NZ_AP028139:c362825-362502 [Polynucleobacter sp. HIN8]
MRYSIVYYSQEVQEEIMNLPVTLQARFIGLTDRMMEHGPNLGLPHTDAFGGGLFELRLKGAEGIARVFFCLIVKQQIVML
HSFIKKTQKTPDKELKLAKQRMKEFKK

Download         Length: 324 bp

>T44571 NZ_AP028139:c362825-362502 [Polynucleobacter sp. HIN8]
ATGAGATATTCCATTGTTTATTACAGTCAAGAGGTACAGGAAGAAATCATGAATTTACCAGTTACGCTTCAAGCTCGATT
TATCGGCTTAACTGACCGAATGATGGAGCATGGACCAAACTTAGGCCTACCTCATACCGACGCATTTGGAGGTGGGCTAT
TTGAATTAAGACTTAAAGGTGCAGAGGGTATTGCACGCGTTTTCTTTTGCTTGATAGTAAAACAACAAATTGTCATGCTC
CATAGCTTTATAAAGAAAACTCAAAAGACCCCAGATAAAGAATTAAAGCTTGCCAAGCAACGCATGAAGGAGTTTAAGAA
ATGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11109.12 Da        Isoelectric Point: 11.3516

>AT44571 WP_286281515.1 NZ_AP028139:c362505-362197 [Polynucleobacter sp. HIN8]
MTTKATKVLTHKQMVNKMLKNSAVKAELHRLNREELSILDEILAARKAAGLSQAQVAKRMGTQAPAIARLESALASGKHS
PSLNTLRKYAAALGKRIELHLV

Download         Length: 309 bp

>AT44571 NZ_AP028139:c362505-362197 [Polynucleobacter sp. HIN8]
ATGACGACTAAAGCTACGAAGGTCCTGACCCACAAACAAATGGTCAACAAGATGCTTAAGAATTCAGCTGTAAAGGCTGA
GCTTCATCGACTAAACCGTGAAGAACTTTCGATTTTGGATGAAATCCTTGCGGCACGAAAAGCGGCTGGATTATCCCAAG
CTCAGGTTGCCAAACGGATGGGAACCCAAGCACCAGCCATTGCAAGACTAGAAAGTGCTTTAGCCTCTGGAAAACATTCC
CCAAGCCTCAATACGCTTCGTAAATATGCGGCTGCTTTGGGTAAGCGAATTGAACTTCACCTGGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References