Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1969912..1970563 Replicon chromosome
Accession NZ_AP028106
Organism Edwardsiella ictaluri strain KH201010

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag QUF09_RS09310 Protein ID WP_198077054.1
Coordinates 1970213..1970563 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2A7U2K2
Locus tag QUF09_RS09305 Protein ID WP_049640646.1
Coordinates 1969912..1970211 (-) Length 100 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUF09_RS09275 (KH201010_18130) 1965489..1966829 - 1341 WP_286274088.1 Fic family protein -
QUF09_RS09280 (KH201010_18140) 1966958..1967728 - 771 WP_198077052.1 Rha family transcriptional regulator -
QUF09_RS09285 (KH201010_18160) 1968183..1968512 + 330 WP_015871332.1 type II toxin-antitoxin system RelE/ParE family toxin -
QUF09_RS09290 (KH201010_18170) 1968502..1968810 + 309 WP_015871333.1 helix-turn-helix transcriptional regulator -
QUF09_RS09295 (KH201010_18180) 1969061..1969318 + 258 WP_198077053.1 DUF4160 domain-containing protein -
QUF09_RS09300 (KH201010_18190) 1969328..1969840 + 513 WP_015871334.1 DUF2442 domain-containing protein -
QUF09_RS09305 (KH201010_18200) 1969912..1970211 - 300 WP_049640646.1 XRE family transcriptional regulator Antitoxin
QUF09_RS09310 (KH201010_18210) 1970213..1970563 - 351 WP_198077054.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QUF09_RS09315 (KH201010_18220) 1970613..1970924 - 312 WP_049640644.1 DUF1364 family protein -
QUF09_RS09320 (KH201010_18230) 1970927..1971571 - 645 WP_198077055.1 DUF1367 family protein -
QUF09_RS09325 (KH201010_18240) 1971681..1972028 - 348 WP_015871339.1 hypothetical protein -
QUF09_RS09330 (KH201010_18250) 1972058..1973440 - 1383 WP_049640642.1 replicative DNA helicase -
QUF09_RS09335 (KH201010_18260) 1973437..1974387 - 951 WP_198077056.1 helix-turn-helix domain-containing protein -
QUF09_RS09340 (KH201010_18270) 1974391..1974579 - 189 WP_198077057.1 hypothetical protein -
QUF09_RS09345 (KH201010_18280) 1974589..1974849 - 261 WP_015871343.1 hypothetical protein -
QUF09_RS09350 (KH201010_18290) 1974881..1975111 - 231 WP_198077058.1 porin -
QUF09_RS09355 (KH201010_18300) 1975108..1975464 - 357 WP_198077059.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1923603..1990698 67095


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-107)

Antitoxin

(32-80)


Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 12907.85 Da        Isoelectric Point: 6.9832

>T44558 WP_198077054.1 NZ_AP028106:c1970563-1970213 [Edwardsiella ictaluri]
VWIVETTAAFDEWFTAQSEALQDEMLAALTVLSEFGPNLGRPIVDTLKGAKLANLKELRVQFAGNPIRAFFAFDPERKAI
VLCAGDKTGINEKRFYNSMIKLAEAEFSSHLKKRGS

Download         Length: 351 bp

>T44558 NZ_AP028106:c1970563-1970213 [Edwardsiella ictaluri]
GTGTGGATCGTTGAAACGACAGCCGCTTTTGATGAGTGGTTTACGGCACAGAGTGAGGCTTTGCAGGACGAAATGCTGGC
CGCTTTAACCGTATTGAGCGAGTTCGGCCCTAACCTCGGACGCCCTATCGTGGATACGTTAAAGGGTGCAAAGCTGGCAA
ACCTTAAGGAGTTGCGGGTTCAGTTCGCCGGTAATCCGATTCGTGCATTTTTTGCATTCGATCCAGAACGAAAAGCAATT
GTGTTATGCGCTGGCGACAAAACAGGCATCAACGAAAAACGGTTCTATAATTCAATGATTAAGCTTGCTGAGGCTGAATT
CAGTAGTCACCTGAAAAAACGAGGTTCTTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11037.74 Da        Isoelectric Point: 9.9190

>AT44558 WP_049640646.1 NZ_AP028106:c1970211-1969912 [Edwardsiella ictaluri]
MATLDKLLAQRSPESRAKIEARADELRREVLLHQLREELSMSQSELAAAMGVKQPTVARMEQPDNDPRLSTLKRYVTALG
GQISIDVTLPTGKRVGFHL

Download         Length: 300 bp

>AT44558 NZ_AP028106:c1970211-1969912 [Edwardsiella ictaluri]
ATGGCAACGCTAGATAAGCTGTTGGCACAGCGTAGTCCTGAAAGTCGCGCGAAAATTGAAGCGCGGGCTGATGAATTGCG
TCGGGAAGTATTGCTCCATCAGCTGAGAGAAGAACTGAGTATGTCACAGAGCGAATTAGCCGCCGCGATGGGGGTAAAAC
AGCCGACAGTGGCAAGAATGGAGCAGCCAGACAACGATCCGCGTTTATCTACGCTTAAACGCTATGTGACCGCCTTGGGC
GGCCAGATAAGTATTGATGTGACGCTACCGACGGGTAAGCGGGTTGGTTTTCACCTCTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A2A7U2K2

References