Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Tad-HTH_37 |
| Location | 1968183..1968810 | Replicon | chromosome |
| Accession | NZ_AP028106 | ||
| Organism | Edwardsiella ictaluri strain KH201010 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A411H7J1 |
| Locus tag | QUF09_RS09285 | Protein ID | WP_015871332.1 |
| Coordinates | 1968183..1968512 (+) | Length | 110 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | C5BBM8 |
| Locus tag | QUF09_RS09290 | Protein ID | WP_015871333.1 |
| Coordinates | 1968502..1968810 (+) | Length | 103 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QUF09_RS09255 (KH201010_18090) | 1963590..1963919 | - | 330 | WP_049640650.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| QUF09_RS09260 (KH201010_18100) | 1963894..1964124 | - | 231 | WP_015871327.1 | ParD-like family protein | - |
| QUF09_RS09265 (KH201010_18110) | 1964256..1964500 | - | 245 | Protein_1782 | transposase | - |
| QUF09_RS09270 (KH201010_18120) | 1964606..1965424 | - | 819 | WP_198077051.1 | hypothetical protein | - |
| QUF09_RS09275 (KH201010_18130) | 1965489..1966829 | - | 1341 | WP_286274088.1 | Fic family protein | - |
| QUF09_RS09280 (KH201010_18140) | 1966958..1967728 | - | 771 | WP_198077052.1 | Rha family transcriptional regulator | - |
| QUF09_RS09285 (KH201010_18160) | 1968183..1968512 | + | 330 | WP_015871332.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| QUF09_RS09290 (KH201010_18170) | 1968502..1968810 | + | 309 | WP_015871333.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| QUF09_RS09295 (KH201010_18180) | 1969061..1969318 | + | 258 | WP_198077053.1 | DUF4160 domain-containing protein | - |
| QUF09_RS09300 (KH201010_18190) | 1969328..1969840 | + | 513 | WP_015871334.1 | DUF2442 domain-containing protein | - |
| QUF09_RS09305 (KH201010_18200) | 1969912..1970211 | - | 300 | WP_049640646.1 | XRE family transcriptional regulator | - |
| QUF09_RS09310 (KH201010_18210) | 1970213..1970563 | - | 351 | WP_198077054.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| QUF09_RS09315 (KH201010_18220) | 1970613..1970924 | - | 312 | WP_049640644.1 | DUF1364 family protein | - |
| QUF09_RS09320 (KH201010_18230) | 1970927..1971571 | - | 645 | WP_198077055.1 | DUF1367 family protein | - |
| QUF09_RS09325 (KH201010_18240) | 1971681..1972028 | - | 348 | WP_015871339.1 | hypothetical protein | - |
| QUF09_RS09330 (KH201010_18250) | 1972058..1973440 | - | 1383 | WP_049640642.1 | replicative DNA helicase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1923603..1990698 | 67095 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 110 a.a. Molecular weight: 12771.78 Da Isoelectric Point: 9.6247
>T44556 WP_015871332.1 NZ_AP028106:1968183-1968512 [Edwardsiella ictaluri]
MNYTIEYYSEEVRLEVDQLPMGMRVRYQHLVERMEIYGSNLGEPHTSPFGDGLFELRIKGSDGIARVFYCTLTGKRIVML
HSFIKKTQKTPSAERKKAETRMKEVKHGW
MNYTIEYYSEEVRLEVDQLPMGMRVRYQHLVERMEIYGSNLGEPHTSPFGDGLFELRIKGSDGIARVFYCTLTGKRIVML
HSFIKKTQKTPSAERKKAETRMKEVKHGW
Download Length: 330 bp
>T44556 NZ_AP028106:1968183-1968512 [Edwardsiella ictaluri]
ATGAACTACACTATTGAGTACTACAGCGAAGAGGTTCGGCTTGAGGTCGATCAGTTGCCAATGGGTATGCGGGTTCGATA
CCAGCATCTCGTTGAACGCATGGAAATCTACGGTAGTAATCTCGGAGAACCACACACAAGCCCTTTTGGCGATGGGCTTT
TTGAGCTTCGAATCAAAGGCAGTGATGGCATCGCCCGCGTGTTTTACTGCACTCTTACCGGAAAACGTATCGTCATGCTG
CACAGCTTCATCAAGAAAACCCAGAAGACGCCAAGCGCTGAACGTAAGAAGGCTGAAACCAGAATGAAGGAGGTAAAACA
TGGCTGGTAA
ATGAACTACACTATTGAGTACTACAGCGAAGAGGTTCGGCTTGAGGTCGATCAGTTGCCAATGGGTATGCGGGTTCGATA
CCAGCATCTCGTTGAACGCATGGAAATCTACGGTAGTAATCTCGGAGAACCACACACAAGCCCTTTTGGCGATGGGCTTT
TTGAGCTTCGAATCAAAGGCAGTGATGGCATCGCCCGCGTGTTTTACTGCACTCTTACCGGAAAACGTATCGTCATGCTG
CACAGCTTCATCAAGAAAACCCAGAAGACGCCAAGCGCTGAACGTAAGAAGGCTGAAACCAGAATGAAGGAGGTAAAACA
TGGCTGGTAA
Antitoxin
Download Length: 103 a.a. Molecular weight: 11207.86 Da Isoelectric Point: 8.5371
>AT44556 WP_015871333.1 NZ_AP028106:1968502-1968810 [Edwardsiella ictaluri]
MAGKRTPPTMTHDEMAAKWMEDPAFKAEYDAIEEEYALLDEMLAARKNAGLTQAQVAERMGTKATAITRMESNLASGQSG
PSFATLKKFAHATGKKLQIRFV
MAGKRTPPTMTHDEMAAKWMEDPAFKAEYDAIEEEYALLDEMLAARKNAGLTQAQVAERMGTKATAITRMESNLASGQSG
PSFATLKKFAHATGKKLQIRFV
Download Length: 309 bp
>AT44556 NZ_AP028106:1968502-1968810 [Edwardsiella ictaluri]
ATGGCTGGTAAACGCACCCCCCCCACGATGACGCATGATGAAATGGCTGCAAAATGGATGGAAGACCCGGCATTTAAAGC
AGAATACGATGCCATCGAAGAGGAATACGCCCTACTCGATGAAATGCTCGCAGCCCGCAAAAACGCGGGGCTGACCCAGG
CGCAGGTCGCCGAACGTATGGGAACCAAGGCTACAGCGATCACTCGCATGGAAAGTAATTTAGCCTCCGGCCAAAGCGGG
CCATCATTCGCCACGCTGAAAAAATTTGCACACGCGACCGGCAAGAAACTGCAGATCCGGTTTGTCTGA
ATGGCTGGTAAACGCACCCCCCCCACGATGACGCATGATGAAATGGCTGCAAAATGGATGGAAGACCCGGCATTTAAAGC
AGAATACGATGCCATCGAAGAGGAATACGCCCTACTCGATGAAATGCTCGCAGCCCGCAAAAACGCGGGGCTGACCCAGG
CGCAGGTCGCCGAACGTATGGGAACCAAGGCTACAGCGATCACTCGCATGGAAAGTAATTTAGCCTCCGGCCAAAGCGGG
CCATCATTCGCCACGCTGAAAAAATTTGCACACGCGACCGGCAAGAAACTGCAGATCCGGTTTGTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A411H7J1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | C5BBM8 |