Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 1969916..1970567 | Replicon | chromosome |
| Accession | NZ_AP028102 | ||
| Organism | Edwardsiella ictaluri strain KB20921 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | QUF12_RS09315 | Protein ID | WP_198077054.1 |
| Coordinates | 1970217..1970567 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | A0A2A7U2K2 |
| Locus tag | QUF12_RS09310 | Protein ID | WP_049640646.1 |
| Coordinates | 1969916..1970215 (-) | Length | 100 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QUF12_RS09280 (KB20921_18210) | 1965493..1966833 | - | 1341 | WP_286274088.1 | Fic family protein | - |
| QUF12_RS09285 (KB20921_18220) | 1966962..1967732 | - | 771 | WP_198077052.1 | Rha family transcriptional regulator | - |
| QUF12_RS09290 (KB20921_18240) | 1968187..1968516 | + | 330 | WP_015871332.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| QUF12_RS09295 (KB20921_18250) | 1968506..1968814 | + | 309 | WP_015871333.1 | helix-turn-helix transcriptional regulator | - |
| QUF12_RS09300 (KB20921_18260) | 1969065..1969322 | + | 258 | WP_198077053.1 | DUF4160 domain-containing protein | - |
| QUF12_RS09305 (KB20921_18270) | 1969332..1969844 | + | 513 | WP_015871334.1 | DUF2442 domain-containing protein | - |
| QUF12_RS09310 (KB20921_18280) | 1969916..1970215 | - | 300 | WP_049640646.1 | XRE family transcriptional regulator | Antitoxin |
| QUF12_RS09315 (KB20921_18290) | 1970217..1970567 | - | 351 | WP_198077054.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| QUF12_RS09320 (KB20921_18300) | 1970617..1970928 | - | 312 | WP_049640644.1 | DUF1364 family protein | - |
| QUF12_RS09325 (KB20921_18310) | 1970931..1971575 | - | 645 | WP_198077055.1 | DUF1367 family protein | - |
| QUF12_RS09330 (KB20921_18320) | 1971685..1972032 | - | 348 | WP_015871339.1 | hypothetical protein | - |
| QUF12_RS09335 (KB20921_18330) | 1972062..1973444 | - | 1383 | WP_049640642.1 | replicative DNA helicase | - |
| QUF12_RS09340 (KB20921_18340) | 1973441..1974391 | - | 951 | WP_198077056.1 | helix-turn-helix domain-containing protein | - |
| QUF12_RS09345 (KB20921_18350) | 1974395..1974583 | - | 189 | WP_198077057.1 | hypothetical protein | - |
| QUF12_RS09350 (KB20921_18360) | 1974593..1974853 | - | 261 | WP_015871343.1 | hypothetical protein | - |
| QUF12_RS09355 (KB20921_18370) | 1974885..1975115 | - | 231 | WP_198077058.1 | porin | - |
| QUF12_RS09360 (KB20921_18380) | 1975112..1975468 | - | 357 | WP_198077059.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1933525..1990701 | 57176 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12907.85 Da Isoelectric Point: 6.9832
>T44550 WP_198077054.1 NZ_AP028102:c1970567-1970217 [Edwardsiella ictaluri]
VWIVETTAAFDEWFTAQSEALQDEMLAALTVLSEFGPNLGRPIVDTLKGAKLANLKELRVQFAGNPIRAFFAFDPERKAI
VLCAGDKTGINEKRFYNSMIKLAEAEFSSHLKKRGS
VWIVETTAAFDEWFTAQSEALQDEMLAALTVLSEFGPNLGRPIVDTLKGAKLANLKELRVQFAGNPIRAFFAFDPERKAI
VLCAGDKTGINEKRFYNSMIKLAEAEFSSHLKKRGS
Download Length: 351 bp
>T44550 NZ_AP028102:c1970567-1970217 [Edwardsiella ictaluri]
GTGTGGATCGTTGAAACGACAGCCGCTTTTGATGAGTGGTTTACGGCACAGAGTGAGGCTTTGCAGGACGAAATGCTGGC
CGCTTTAACCGTATTGAGCGAGTTCGGCCCTAACCTCGGACGCCCTATCGTGGATACGTTAAAGGGTGCAAAGCTGGCAA
ACCTTAAGGAGTTGCGGGTTCAGTTCGCCGGTAATCCGATTCGTGCATTTTTTGCATTCGATCCAGAACGAAAAGCAATT
GTGTTATGCGCTGGCGACAAAACAGGCATCAACGAAAAACGGTTCTATAATTCAATGATTAAGCTTGCTGAGGCTGAATT
CAGTAGTCACCTGAAAAAACGAGGTTCTTAA
GTGTGGATCGTTGAAACGACAGCCGCTTTTGATGAGTGGTTTACGGCACAGAGTGAGGCTTTGCAGGACGAAATGCTGGC
CGCTTTAACCGTATTGAGCGAGTTCGGCCCTAACCTCGGACGCCCTATCGTGGATACGTTAAAGGGTGCAAAGCTGGCAA
ACCTTAAGGAGTTGCGGGTTCAGTTCGCCGGTAATCCGATTCGTGCATTTTTTGCATTCGATCCAGAACGAAAAGCAATT
GTGTTATGCGCTGGCGACAAAACAGGCATCAACGAAAAACGGTTCTATAATTCAATGATTAAGCTTGCTGAGGCTGAATT
CAGTAGTCACCTGAAAAAACGAGGTTCTTAA
Antitoxin
Download Length: 100 a.a. Molecular weight: 11037.74 Da Isoelectric Point: 9.9190
>AT44550 WP_049640646.1 NZ_AP028102:c1970215-1969916 [Edwardsiella ictaluri]
MATLDKLLAQRSPESRAKIEARADELRREVLLHQLREELSMSQSELAAAMGVKQPTVARMEQPDNDPRLSTLKRYVTALG
GQISIDVTLPTGKRVGFHL
MATLDKLLAQRSPESRAKIEARADELRREVLLHQLREELSMSQSELAAAMGVKQPTVARMEQPDNDPRLSTLKRYVTALG
GQISIDVTLPTGKRVGFHL
Download Length: 300 bp
>AT44550 NZ_AP028102:c1970215-1969916 [Edwardsiella ictaluri]
ATGGCAACGCTAGATAAGCTGTTGGCACAGCGTAGTCCTGAAAGTCGCGCGAAAATTGAAGCGCGGGCTGATGAATTGCG
TCGGGAAGTATTGCTCCATCAGCTGAGAGAAGAACTGAGTATGTCACAGAGCGAATTAGCCGCCGCGATGGGGGTAAAAC
AGCCGACAGTGGCAAGAATGGAGCAGCCAGACAACGATCCGCGTTTATCTACGCTTAAACGCTATGTGACCGCCTTGGGC
GGCCAGATAAGTATTGATGTGACGCTACCGACGGGTAAGCGGGTTGGTTTTCACCTCTAA
ATGGCAACGCTAGATAAGCTGTTGGCACAGCGTAGTCCTGAAAGTCGCGCGAAAATTGAAGCGCGGGCTGATGAATTGCG
TCGGGAAGTATTGCTCCATCAGCTGAGAGAAGAACTGAGTATGTCACAGAGCGAATTAGCCGCCGCGATGGGGGTAAAAC
AGCCGACAGTGGCAAGAATGGAGCAGCCAGACAACGATCCGCGTTTATCTACGCTTAAACGCTATGTGACCGCCTTGGGC
GGCCAGATAAGTATTGATGTGACGCTACCGACGGGTAAGCGGGTTGGTTTTCACCTCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|