Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 1968187..1968814 Replicon chromosome
Accession NZ_AP028102
Organism Edwardsiella ictaluri strain KB20921

Toxin (Protein)


Gene name higB Uniprot ID A0A411H7J1
Locus tag QUF12_RS09290 Protein ID WP_015871332.1
Coordinates 1968187..1968516 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID C5BBM8
Locus tag QUF12_RS09295 Protein ID WP_015871333.1
Coordinates 1968506..1968814 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUF12_RS09260 (KB20921_18170) 1963594..1963923 - 330 WP_049640650.1 type II toxin-antitoxin system RelE/ParE family toxin -
QUF12_RS09265 (KB20921_18180) 1963898..1964128 - 231 WP_015871327.1 ParD-like family protein -
QUF12_RS09270 (KB20921_18190) 1964260..1964504 - 245 Protein_1783 transposase -
QUF12_RS09275 (KB20921_18200) 1964610..1965428 - 819 WP_198077051.1 hypothetical protein -
QUF12_RS09280 (KB20921_18210) 1965493..1966833 - 1341 WP_286274088.1 Fic family protein -
QUF12_RS09285 (KB20921_18220) 1966962..1967732 - 771 WP_198077052.1 Rha family transcriptional regulator -
QUF12_RS09290 (KB20921_18240) 1968187..1968516 + 330 WP_015871332.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QUF12_RS09295 (KB20921_18250) 1968506..1968814 + 309 WP_015871333.1 helix-turn-helix transcriptional regulator Antitoxin
QUF12_RS09300 (KB20921_18260) 1969065..1969322 + 258 WP_198077053.1 DUF4160 domain-containing protein -
QUF12_RS09305 (KB20921_18270) 1969332..1969844 + 513 WP_015871334.1 DUF2442 domain-containing protein -
QUF12_RS09310 (KB20921_18280) 1969916..1970215 - 300 WP_049640646.1 XRE family transcriptional regulator -
QUF12_RS09315 (KB20921_18290) 1970217..1970567 - 351 WP_198077054.1 type II toxin-antitoxin system RelE/ParE family toxin -
QUF12_RS09320 (KB20921_18300) 1970617..1970928 - 312 WP_049640644.1 DUF1364 family protein -
QUF12_RS09325 (KB20921_18310) 1970931..1971575 - 645 WP_198077055.1 DUF1367 family protein -
QUF12_RS09330 (KB20921_18320) 1971685..1972032 - 348 WP_015871339.1 hypothetical protein -
QUF12_RS09335 (KB20921_18330) 1972062..1973444 - 1383 WP_049640642.1 replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1933525..1990701 57176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-97)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12771.78 Da        Isoelectric Point: 9.6247

>T44548 WP_015871332.1 NZ_AP028102:1968187-1968516 [Edwardsiella ictaluri]
MNYTIEYYSEEVRLEVDQLPMGMRVRYQHLVERMEIYGSNLGEPHTSPFGDGLFELRIKGSDGIARVFYCTLTGKRIVML
HSFIKKTQKTPSAERKKAETRMKEVKHGW

Download         Length: 330 bp

>T44548 NZ_AP028102:1968187-1968516 [Edwardsiella ictaluri]
ATGAACTACACTATTGAGTACTACAGCGAAGAGGTTCGGCTTGAGGTCGATCAGTTGCCAATGGGTATGCGGGTTCGATA
CCAGCATCTCGTTGAACGCATGGAAATCTACGGTAGTAATCTCGGAGAACCACACACAAGCCCTTTTGGCGATGGGCTTT
TTGAGCTTCGAATCAAAGGCAGTGATGGCATCGCCCGCGTGTTTTACTGCACTCTTACCGGAAAACGTATCGTCATGCTG
CACAGCTTCATCAAGAAAACCCAGAAGACGCCAAGCGCTGAACGTAAGAAGGCTGAAACCAGAATGAAGGAGGTAAAACA
TGGCTGGTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11207.86 Da        Isoelectric Point: 8.5371

>AT44548 WP_015871333.1 NZ_AP028102:1968506-1968814 [Edwardsiella ictaluri]
MAGKRTPPTMTHDEMAAKWMEDPAFKAEYDAIEEEYALLDEMLAARKNAGLTQAQVAERMGTKATAITRMESNLASGQSG
PSFATLKKFAHATGKKLQIRFV

Download         Length: 309 bp

>AT44548 NZ_AP028102:1968506-1968814 [Edwardsiella ictaluri]
ATGGCTGGTAAACGCACCCCCCCCACGATGACGCATGATGAAATGGCTGCAAAATGGATGGAAGACCCGGCATTTAAAGC
AGAATACGATGCCATCGAAGAGGAATACGCCCTACTCGATGAAATGCTCGCAGCCCGCAAAAACGCGGGGCTGACCCAGG
CGCAGGTCGCCGAACGTATGGGAACCAAGGCTACAGCGATCACTCGCATGGAAAGTAATTTAGCCTCCGGCCAAAGCGGG
CCATCATTCGCCACGCTGAAAAAATTTGCACACGCGACCGGCAAGAAACTGCAGATCCGGTTTGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A411H7J1

Antitoxin

Source ID Structure
AlphaFold DB C5BBM8

References