Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 1936653..1937304 | Replicon | chromosome |
| Accession | NZ_AP028097 | ||
| Organism | Edwardsiella ictaluri strain KH20906 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | QUE95_RS09195 | Protein ID | WP_198077054.1 |
| Coordinates | 1936954..1937304 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | A0A2A7U2K2 |
| Locus tag | QUE95_RS09190 | Protein ID | WP_049640646.1 |
| Coordinates | 1936653..1936952 (-) | Length | 100 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QUE95_RS09160 (KH20906_17960) | 1932230..1933570 | - | 1341 | WP_286274088.1 | Fic family protein | - |
| QUE95_RS09165 (KH20906_17970) | 1933699..1934469 | - | 771 | WP_198077052.1 | Rha family transcriptional regulator | - |
| QUE95_RS09170 (KH20906_17990) | 1934924..1935253 | + | 330 | WP_015871332.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| QUE95_RS09175 (KH20906_18000) | 1935243..1935551 | + | 309 | WP_015871333.1 | helix-turn-helix transcriptional regulator | - |
| QUE95_RS09180 (KH20906_18010) | 1935802..1936059 | + | 258 | WP_198077053.1 | DUF4160 domain-containing protein | - |
| QUE95_RS09185 (KH20906_18020) | 1936069..1936581 | + | 513 | WP_015871334.1 | DUF2442 domain-containing protein | - |
| QUE95_RS09190 (KH20906_18030) | 1936653..1936952 | - | 300 | WP_049640646.1 | XRE family transcriptional regulator | Antitoxin |
| QUE95_RS09195 (KH20906_18040) | 1936954..1937304 | - | 351 | WP_198077054.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| QUE95_RS09200 (KH20906_18050) | 1937354..1937665 | - | 312 | WP_049640644.1 | DUF1364 family protein | - |
| QUE95_RS09205 (KH20906_18060) | 1937668..1938312 | - | 645 | WP_198077055.1 | DUF1367 family protein | - |
| QUE95_RS09210 (KH20906_18070) | 1938422..1938769 | - | 348 | WP_015871339.1 | hypothetical protein | - |
| QUE95_RS09215 (KH20906_18080) | 1938799..1940181 | - | 1383 | WP_049640642.1 | replicative DNA helicase | - |
| QUE95_RS09220 (KH20906_18090) | 1940178..1941128 | - | 951 | WP_198077056.1 | helix-turn-helix domain-containing protein | - |
| QUE95_RS09225 (KH20906_18100) | 1941132..1941320 | - | 189 | WP_198077057.1 | hypothetical protein | - |
| QUE95_RS09230 (KH20906_18110) | 1941330..1941590 | - | 261 | WP_015871343.1 | hypothetical protein | - |
| QUE95_RS09235 (KH20906_18120) | 1941622..1941852 | - | 231 | WP_198077058.1 | porin | - |
| QUE95_RS09240 (KH20906_18130) | 1941849..1942205 | - | 357 | WP_198077059.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1899460..1957438 | 57978 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12907.85 Da Isoelectric Point: 6.9832
>T44542 WP_198077054.1 NZ_AP028097:c1937304-1936954 [Edwardsiella ictaluri]
VWIVETTAAFDEWFTAQSEALQDEMLAALTVLSEFGPNLGRPIVDTLKGAKLANLKELRVQFAGNPIRAFFAFDPERKAI
VLCAGDKTGINEKRFYNSMIKLAEAEFSSHLKKRGS
VWIVETTAAFDEWFTAQSEALQDEMLAALTVLSEFGPNLGRPIVDTLKGAKLANLKELRVQFAGNPIRAFFAFDPERKAI
VLCAGDKTGINEKRFYNSMIKLAEAEFSSHLKKRGS
Download Length: 351 bp
>T44542 NZ_AP028097:c1937304-1936954 [Edwardsiella ictaluri]
GTGTGGATCGTTGAAACGACAGCCGCTTTTGATGAGTGGTTTACGGCACAGAGTGAGGCTTTGCAGGACGAAATGCTGGC
CGCTTTAACCGTATTGAGCGAGTTCGGCCCTAACCTCGGACGCCCTATCGTGGATACGTTAAAGGGTGCAAAGCTGGCAA
ACCTTAAGGAGTTGCGGGTTCAGTTCGCCGGTAATCCGATTCGTGCATTTTTTGCATTCGATCCAGAACGAAAAGCAATT
GTGTTATGCGCTGGCGACAAAACAGGCATCAACGAAAAACGGTTCTATAATTCAATGATTAAGCTTGCTGAGGCTGAATT
CAGTAGTCACCTGAAAAAACGAGGTTCTTAA
GTGTGGATCGTTGAAACGACAGCCGCTTTTGATGAGTGGTTTACGGCACAGAGTGAGGCTTTGCAGGACGAAATGCTGGC
CGCTTTAACCGTATTGAGCGAGTTCGGCCCTAACCTCGGACGCCCTATCGTGGATACGTTAAAGGGTGCAAAGCTGGCAA
ACCTTAAGGAGTTGCGGGTTCAGTTCGCCGGTAATCCGATTCGTGCATTTTTTGCATTCGATCCAGAACGAAAAGCAATT
GTGTTATGCGCTGGCGACAAAACAGGCATCAACGAAAAACGGTTCTATAATTCAATGATTAAGCTTGCTGAGGCTGAATT
CAGTAGTCACCTGAAAAAACGAGGTTCTTAA
Antitoxin
Download Length: 100 a.a. Molecular weight: 11037.74 Da Isoelectric Point: 9.9190
>AT44542 WP_049640646.1 NZ_AP028097:c1936952-1936653 [Edwardsiella ictaluri]
MATLDKLLAQRSPESRAKIEARADELRREVLLHQLREELSMSQSELAAAMGVKQPTVARMEQPDNDPRLSTLKRYVTALG
GQISIDVTLPTGKRVGFHL
MATLDKLLAQRSPESRAKIEARADELRREVLLHQLREELSMSQSELAAAMGVKQPTVARMEQPDNDPRLSTLKRYVTALG
GQISIDVTLPTGKRVGFHL
Download Length: 300 bp
>AT44542 NZ_AP028097:c1936952-1936653 [Edwardsiella ictaluri]
ATGGCAACGCTAGATAAGCTGTTGGCACAGCGTAGTCCTGAAAGTCGCGCGAAAATTGAAGCGCGGGCTGATGAATTGCG
TCGGGAAGTATTGCTCCATCAGCTGAGAGAAGAACTGAGTATGTCACAGAGCGAATTAGCCGCCGCGATGGGGGTAAAAC
AGCCGACAGTGGCAAGAATGGAGCAGCCAGACAACGATCCGCGTTTATCTACGCTTAAACGCTATGTGACCGCCTTGGGC
GGCCAGATAAGTATTGATGTGACGCTACCGACGGGTAAGCGGGTTGGTTTTCACCTCTAA
ATGGCAACGCTAGATAAGCTGTTGGCACAGCGTAGTCCTGAAAGTCGCGCGAAAATTGAAGCGCGGGCTGATGAATTGCG
TCGGGAAGTATTGCTCCATCAGCTGAGAGAAGAACTGAGTATGTCACAGAGCGAATTAGCCGCCGCGATGGGGGTAAAAC
AGCCGACAGTGGCAAGAATGGAGCAGCCAGACAACGATCCGCGTTTATCTACGCTTAAACGCTATGTGACCGCCTTGGGC
GGCCAGATAAGTATTGATGTGACGCTACCGACGGGTAAGCGGGTTGGTTTTCACCTCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|