Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 1934924..1935551 Replicon chromosome
Accession NZ_AP028097
Organism Edwardsiella ictaluri strain KH20906

Toxin (Protein)


Gene name higB Uniprot ID A0A411H7J1
Locus tag QUE95_RS09170 Protein ID WP_015871332.1
Coordinates 1934924..1935253 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID C5BBM8
Locus tag QUE95_RS09175 Protein ID WP_015871333.1
Coordinates 1935243..1935551 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE95_RS09140 (KH20906_17920) 1930331..1930660 - 330 WP_049640650.1 type II toxin-antitoxin system RelE/ParE family toxin -
QUE95_RS09145 (KH20906_17930) 1930635..1930865 - 231 WP_015871327.1 ParD-like family protein -
QUE95_RS09150 (KH20906_17940) 1930997..1931241 - 245 Protein_1759 transposase -
QUE95_RS09155 (KH20906_17950) 1931347..1932165 - 819 WP_198077051.1 hypothetical protein -
QUE95_RS09160 (KH20906_17960) 1932230..1933570 - 1341 WP_286274088.1 Fic family protein -
QUE95_RS09165 (KH20906_17970) 1933699..1934469 - 771 WP_198077052.1 Rha family transcriptional regulator -
QUE95_RS09170 (KH20906_17990) 1934924..1935253 + 330 WP_015871332.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QUE95_RS09175 (KH20906_18000) 1935243..1935551 + 309 WP_015871333.1 helix-turn-helix transcriptional regulator Antitoxin
QUE95_RS09180 (KH20906_18010) 1935802..1936059 + 258 WP_198077053.1 DUF4160 domain-containing protein -
QUE95_RS09185 (KH20906_18020) 1936069..1936581 + 513 WP_015871334.1 DUF2442 domain-containing protein -
QUE95_RS09190 (KH20906_18030) 1936653..1936952 - 300 WP_049640646.1 XRE family transcriptional regulator -
QUE95_RS09195 (KH20906_18040) 1936954..1937304 - 351 WP_198077054.1 type II toxin-antitoxin system RelE/ParE family toxin -
QUE95_RS09200 (KH20906_18050) 1937354..1937665 - 312 WP_049640644.1 DUF1364 family protein -
QUE95_RS09205 (KH20906_18060) 1937668..1938312 - 645 WP_198077055.1 DUF1367 family protein -
QUE95_RS09210 (KH20906_18070) 1938422..1938769 - 348 WP_015871339.1 hypothetical protein -
QUE95_RS09215 (KH20906_18080) 1938799..1940181 - 1383 WP_049640642.1 replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1899460..1957438 57978


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-97)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12771.78 Da        Isoelectric Point: 9.6247

>T44540 WP_015871332.1 NZ_AP028097:1934924-1935253 [Edwardsiella ictaluri]
MNYTIEYYSEEVRLEVDQLPMGMRVRYQHLVERMEIYGSNLGEPHTSPFGDGLFELRIKGSDGIARVFYCTLTGKRIVML
HSFIKKTQKTPSAERKKAETRMKEVKHGW

Download         Length: 330 bp

>T44540 NZ_AP028097:1934924-1935253 [Edwardsiella ictaluri]
ATGAACTACACTATTGAGTACTACAGCGAAGAGGTTCGGCTTGAGGTCGATCAGTTGCCAATGGGTATGCGGGTTCGATA
CCAGCATCTCGTTGAACGCATGGAAATCTACGGTAGTAATCTCGGAGAACCACACACAAGCCCTTTTGGCGATGGGCTTT
TTGAGCTTCGAATCAAAGGCAGTGATGGCATCGCCCGCGTGTTTTACTGCACTCTTACCGGAAAACGTATCGTCATGCTG
CACAGCTTCATCAAGAAAACCCAGAAGACGCCAAGCGCTGAACGTAAGAAGGCTGAAACCAGAATGAAGGAGGTAAAACA
TGGCTGGTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11207.86 Da        Isoelectric Point: 8.5371

>AT44540 WP_015871333.1 NZ_AP028097:1935243-1935551 [Edwardsiella ictaluri]
MAGKRTPPTMTHDEMAAKWMEDPAFKAEYDAIEEEYALLDEMLAARKNAGLTQAQVAERMGTKATAITRMESNLASGQSG
PSFATLKKFAHATGKKLQIRFV

Download         Length: 309 bp

>AT44540 NZ_AP028097:1935243-1935551 [Edwardsiella ictaluri]
ATGGCTGGTAAACGCACCCCCCCCACGATGACGCATGATGAAATGGCTGCAAAATGGATGGAAGACCCGGCATTTAAAGC
AGAATACGATGCCATCGAAGAGGAATACGCCCTACTCGATGAAATGCTCGCAGCCCGCAAAAACGCGGGGCTGACCCAGG
CGCAGGTCGCCGAACGTATGGGAACCAAGGCTACAGCGATCACTCGCATGGAAAGTAATTTAGCCTCCGGCCAAAGCGGG
CCATCATTCGCCACGCTGAAAAAATTTGCACACGCGACCGGCAAGAAACTGCAGATCCGGTTTGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A411H7J1

Antitoxin

Source ID Structure
AlphaFold DB C5BBM8

References