Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/MqsA(antitoxin)
Location 4229004..4229595 Replicon chromosome
Accession NZ_AP028062
Organism Marinobacter shengliensis strain D49

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag QUE75_RS19340 Protein ID WP_286252646.1
Coordinates 4229284..4229595 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QUE75_RS19335 Protein ID WP_286252644.1
Coordinates 4229004..4229291 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE75_RS19300 (MAALD49_38410) 4225083..4225859 - 777 WP_286252632.1 transporter substrate-binding domain-containing protein -
QUE75_RS19305 (MAALD49_38420) 4225902..4226771 - 870 WP_286252635.1 LysR family transcriptional regulator -
QUE75_RS19310 (MAALD49_38430) 4226866..4227366 + 501 WP_106693235.1 lactoylglutathione lyase family protein -
QUE75_RS19315 (MAALD49_38440) 4227720..4227971 + 252 WP_106693233.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
QUE75_RS19320 (MAALD49_38450) 4227968..4228222 + 255 WP_286252638.1 Txe/YoeB family addiction module toxin -
QUE75_RS19325 (MAALD49_38460) 4228360..4228605 + 246 WP_286252640.1 type II toxin-antitoxin system CcdA family antitoxin -
QUE75_RS19330 (MAALD49_38470) 4228605..4228922 + 318 WP_203301045.1 CcdB family protein -
QUE75_RS19335 (MAALD49_38480) 4229004..4229291 - 288 WP_286252644.1 helix-turn-helix domain-containing protein Antitoxin
QUE75_RS19340 (MAALD49_38490) 4229284..4229595 - 312 WP_286252646.1 hypothetical protein Toxin
QUE75_RS19345 (MAALD49_38500) 4229725..4229961 - 237 WP_286252648.1 hypothetical protein -
QUE75_RS19350 (MAALD49_38510) 4230180..4231085 - 906 WP_286252650.1 toll/interleukin-1 receptor domain-containing protein -
QUE75_RS19355 (MAALD49_38520) 4231307..4232878 - 1572 WP_286250329.1 transposase -
QUE75_RS19360 (MAALD49_38530) 4233041..4233346 - 306 WP_286252651.1 hypothetical protein -
QUE75_RS19365 (MAALD49_38540) 4233454..4234479 + 1026 WP_286252653.1 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4229004..4245363 16359
- inside Integron - - 4227588..4231085 3497


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin MqsA/HigA-2

(33-93)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11446.20 Da        Isoelectric Point: 10.0168

>T44466 WP_286252646.1 NZ_AP028062:c4229595-4229284 [Marinobacter shengliensis]
MLFIETSTFTKLLPNYLTDGEYRGLQTYLLQKPDAGDLIKGSGGVRIVRWAPAGSGKSGGIRAIYYWKKSDHEIWMLTLY
SKSERASIPGHALKQIAEAIKNG

Download         Length: 312 bp

>T44466 NZ_AP028062:c4229595-4229284 [Marinobacter shengliensis]
ATGCTATTCATCGAAACCTCAACGTTCACCAAGCTATTGCCGAACTACCTCACGGACGGGGAATACCGTGGGCTTCAAAC
CTACCTTTTGCAGAAGCCGGATGCCGGGGATCTAATCAAAGGCTCGGGTGGTGTTCGTATAGTTCGATGGGCACCAGCGG
GTTCGGGAAAGAGCGGTGGTATCAGAGCTATCTACTACTGGAAGAAGTCTGACCACGAGATATGGATGCTCACGCTGTAC
AGTAAATCAGAGCGGGCCAGCATTCCTGGCCATGCGCTCAAGCAGATAGCGGAGGCAATCAAAAATGGGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10664.31 Da        Isoelectric Point: 9.8632

>AT44466 WP_286252644.1 NZ_AP028062:c4229291-4229004 [Marinobacter shengliensis]
MGDRNLGAEILDGINEIKQFKKGKLALRTHELSEPSPPKVIRLKLNMSQSAFAGLMGVSVRTLQDWEQGRREPQGPAVAL
LRIAEQHPEVFNQLY

Download         Length: 288 bp

>AT44466 NZ_AP028062:c4229291-4229004 [Marinobacter shengliensis]
ATGGGTGACAGGAACCTTGGGGCAGAGATTCTTGATGGCATCAATGAAATAAAGCAGTTCAAGAAGGGCAAATTGGCTCT
ACGAACCCATGAGCTATCAGAGCCCTCACCGCCTAAAGTGATCAGGCTGAAGTTGAACATGTCGCAATCTGCATTTGCCG
GTCTTATGGGCGTGAGTGTACGAACGCTTCAGGATTGGGAGCAGGGTCGTCGTGAGCCGCAGGGGCCTGCAGTTGCGCTT
CTGCGCATTGCTGAGCAACACCCGGAAGTTTTCAATCAGCTTTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References