Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1974157..1974815 Replicon chromosome
Accession NZ_AP028050
Organism Phytobacter diazotrophicus strain TA9832

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag QUE83_RS09235 Protein ID WP_125124251.1
Coordinates 1974157..1974510 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A348DBJ5
Locus tag QUE83_RS09240 Protein ID WP_071196363.1
Coordinates 1974513..1974815 (+) Length 101 a.a.

Genomic Context

QUE83_RS09235QUE83_RS09240QUE83_RS09245QUE83_RS09260QUE83_RS09265QUE83_RS09220QUE83_RS09225QUE83_RS09230QUE83_RS09250QUE83_RS09270
Location: 1974157..1974510 (354 bp)
Type: Toxin
Protein ID: WP_125124251.1
Location: 1974513..1974815 (303 bp)
Type: Antitoxin
Protein ID: WP_071196363.1
Location: 1974892..1975842 (951 bp)
Type: Others
Protein ID: WP_041851855.1
Location: 1976721..1977638 (918 bp)
Type: Others
Protein ID: WP_041851853.1
Location: 1977740..1978690 (951 bp)
Type: Others
Protein ID: WP_041851852.1
Location: 1970611..1972065 (1455 bp)
Type: Others
Protein ID: WP_041851859.1
Location: 1972259..1973188 (930 bp)
Type: Others
Protein ID: WP_232034419.1
Location: 1973118..1973938 (821 bp)
Type: Others
Protein ID: Protein_1805
Location: 1975935..1976123 (189 bp)
Type: Others
Protein ID: WP_041851854.1
Location: 1978742..1979218 (477 bp)
Type: Others
Protein ID: WP_071196365.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
QUE83_RS09220 (1970611)1970611..1972065-1455WP_041851859.1AMP nucleosidase-
QUE83_RS09225 (1972259)1972259..1973188-930WP_232034419.1MDR family oxidoreductase-
QUE83_RS09230 (1973118)1973118..1973938-821Protein_1805TetR family transcriptional regulator C-terminal domain-containing protein-
QUE83_RS09235 (1974157)1974157..1974510+354WP_125124251.1type II toxin-antitoxin system RelE/ParE family toxinToxin
QUE83_RS09240 (1974513)1974513..1974815+303WP_071196363.1XRE family transcriptional regulatorAntitoxin
QUE83_RS09245 (1974892)1974892..1975842+951WP_041851855.1L,D-transpeptidase-
QUE83_RS09250 (1975935)1975935..1976123-189WP_041851854.1YjfB family protein-
QUE83_RS09260 (1976721)1976721..1977638+918WP_041851853.1nitrogen assimilation transcriptional regulator NAC-
QUE83_RS09265 (1977740)1977740..1978690+951WP_041851852.1HTH-type transcriptional regulator Cbl-
QUE83_RS09270 (1978742)1978742..1979218-477WP_071196365.1GNAT family N-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--1934201..203360699405


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13585.60 Da        Isoelectric Point: 9.4816

>T44436 WP_125124251.1 NZ_AP028050:1974157-1974510 [Phytobacter diazotrophicus]
VWEIKTTDRFDEWLIAQNDHTRASVLAALIVLRTKGPELPRPWADTIKGARYSNMKELRIQCRGEPIRPFFAFDPRRAAI
VLCAGSKAGNEKRFYAEMISRAEQEYANYLKKPEKEE

Download         Length: 354 bp

>T44436 NZ_AP028050:1974157-1974510 [Phytobacter diazotrophicus]
GTGTGGGAAATTAAAACAACGGACAGGTTTGATGAGTGGTTAATCGCTCAAAATGATCACACGCGTGCGAGCGTTTTGGC
GGCGCTGATCGTGTTGCGAACGAAAGGCCCCGAATTGCCCAGACCCTGGGCCGACACGATAAAAGGGGCGCGCTACAGCA
ATATGAAGGAGCTGCGAATTCAGTGTCGTGGGGAGCCGATACGCCCTTTTTTCGCTTTTGATCCCAGACGGGCGGCTATT
GTGTTGTGCGCAGGAAGTAAAGCTGGAAATGAAAAACGTTTCTACGCCGAAATGATTTCGCGAGCTGAGCAGGAATATGC
AAACTATCTGAAAAAACCAGAGAAAGAGGAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11067.80 Da        Isoelectric Point: 6.2312

>AT44436 WP_071196363.1 NZ_AP028050:1974513-1974815 [Phytobacter diazotrophicus]
MGRTLEQLLADEKPEVVAQAESMATETLLNIHLAELREKVQKTQVEMAHALGIRQPTVAGMEKPGRDVKLSTLKRYVEAT
GGKLRLDIELPDGSHYAFVV

Download         Length: 303 bp

>AT44436 NZ_AP028050:1974513-1974815 [Phytobacter diazotrophicus]
ATGGGCAGAACGCTGGAACAACTGCTTGCGGATGAAAAACCAGAGGTTGTGGCGCAGGCTGAGTCAATGGCGACTGAGAC
TCTCCTGAACATTCACCTGGCCGAACTGCGTGAGAAAGTGCAAAAAACGCAGGTGGAAATGGCGCATGCACTGGGGATAC
GGCAACCTACGGTGGCGGGAATGGAAAAACCGGGTCGCGATGTAAAACTGTCGACGCTTAAGCGCTACGTTGAAGCCACT
GGCGGTAAGCTTCGTCTTGATATCGAACTGCCTGATGGGTCGCATTACGCCTTCGTTGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A348DBJ5

References