Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3851325..3851583 Replicon chromosome
Accession NZ_AP027963
Organism Escherichia coli strain VE-T9

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag QQK52_RS18835 Protein ID WP_000809168.1
Coordinates 3851431..3851583 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 3851325..3851382 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQK52_RS18805 3846846..3847064 - 219 WP_001295417.1 DUF2575 family protein -
QQK52_RS18810 3847167..3847430 + 264 WP_001274021.1 30S ribosomal protein S20 -
QQK52_RS18815 3847737..3848434 + 698 WP_249438933.1 IS1-like element IS1A family transposase -
QQK52_RS18820 3848449..3848676 + 228 Protein_3683 fimbrial family protein -
QQK52_RS18825 3848714..3849613 - 900 WP_001338226.1 transcriptional activator NhaR -
QQK52_RS18830 3849679..3850845 - 1167 WP_000681362.1 Na+/H+ antiporter NhaA -
- 3851325..3851382 - 58 - - Antitoxin
QQK52_RS18835 3851431..3851583 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
QQK52_RS18840 3851661..3852773 + 1113 WP_001300563.1 IS4-like element IS421 family transposase -
QQK52_RS18845 3853036..3854166 - 1131 WP_001118475.1 molecular chaperone DnaJ -
QQK52_RS18850 3854255..3856171 - 1917 WP_000516135.1 molecular chaperone DnaK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 3847931..3852936 5005


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T44321 WP_000809168.1 NZ_AP027963:3851431-3851583 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T44321 NZ_AP027963:3851431-3851583 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT44321 NZ_AP027963:c3851382-3851325 [Escherichia coli]
GTTCAGCATATAGGAGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References