Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 39919..40173 | Replicon | plasmid pVE-T2_1 |
| Accession | NZ_AP027961 | ||
| Organism | Escherichia coli strain VE-T2 | ||
Toxin (Protein)
| Gene name | srnB | Uniprot ID | G9G1E3 |
| Locus tag | QQK13_RS24020 | Protein ID | WP_001312851.1 |
| Coordinates | 39919..40068 (-) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | srnC | ||
| Locus tag | - | ||
| Coordinates | 40112..40173 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QQK13_RS23985 (35940) | 35940..36440 | + | 501 | Protein_41 | Tn3 family transposase | - |
| QQK13_RS23990 (36474) | 36474..36662 | + | 189 | Protein_42 | IS3 family transposase | - |
| QQK13_RS23995 (36737) | 36737..37024 | - | 288 | WP_000222766.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| QQK13_RS24000 (37021) | 37021..37272 | - | 252 | WP_001132900.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| QQK13_RS24005 (38238) | 38238..39095 | - | 858 | WP_039002220.1 | incFII family plasmid replication initiator RepA | - |
| QQK13_RS24010 (39088) | 39088..39162 | - | 75 | WP_061357229.1 | RepA leader peptide Tap | - |
| QQK13_RS24015 (39394) | 39394..39651 | - | 258 | WP_001541895.1 | replication regulatory protein RepA | - |
| QQK13_RS24020 (39919) | 39919..40068 | - | 150 | WP_001312851.1 | Hok/Gef family protein | Toxin |
| - (40112) | 40112..40173 | + | 62 | NuclAT_0 | - | Antitoxin |
| - (40112) | 40112..40173 | + | 62 | NuclAT_0 | - | Antitoxin |
| - (40112) | 40112..40173 | + | 62 | NuclAT_0 | - | Antitoxin |
| - (40112) | 40112..40173 | + | 62 | NuclAT_0 | - | Antitoxin |
| QQK13_RS24025 (40515) | 40515..40727 | - | 213 | WP_001541896.1 | ANR family transcriptional regulator | - |
| QQK13_RS24030 (40862) | 40862..41422 | - | 561 | WP_000139310.1 | fertility inhibition protein FinO | - |
| QQK13_RS24035 (41477) | 41477..42091 | - | 615 | Protein_51 | conjugal transfer pilus acetylase TraX | - |
| QQK13_RS24040 (42089) | 42089..43255 | - | 1167 | Protein_52 | type IV secretion system DNA-binding domain-containing protein | - |
| QQK13_RS24045 (43321) | 43321..43554 | - | 234 | WP_000005990.1 | DUF905 family protein | - |
| QQK13_RS24050 (43611) | 43611..44150 | - | 540 | WP_000290801.1 | single-stranded DNA-binding protein | - |
| QQK13_RS24055 (44468) | 44468..44977 | + | 510 | WP_071600123.1 | hypothetical protein | - |
| QQK13_RS24060 (44947) | 44947..45138 | - | 192 | WP_001027495.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | tet(M) / ant(3'')-Ia / cmlA1 / aadA2 / dfrA12 / floR / sul2 / aac(3)-IId / sitABCD | iutA / iucD / iucC / iucB / iucA | 1..88388 | 88388 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5542.67 Da Isoelectric Point: 8.7678
>T44296 WP_001312851.1 NZ_AP027961:c40068-39919 [Escherichia coli]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
>T44296 NZ_AP027961:c40068-39919 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACTGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACTGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
Antitoxin
Download Length: 62 bp
>AT44296 NZ_AP027961:40112-40173 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
